国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
16期
1231-1234
,共4页
肺%原发性%间变性%淋巴瘤
肺%原髮性%間變性%淋巴瘤
폐%원발성%간변성%림파류
Lung%Primary%Anaplastic%Lymphoma
目的 探讨肺原发性间变性大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL)临床病理特点、免疫组化特点、鉴别诊断、治疗和诊断技术，以提高对肺原发性ALCL的认识。方法 通过本病例及复习相关的文献资料，回顾性分析病例的临床特征、组织细胞形态学和免疫组化特点。结果 肺原发性ALCL的临床特点以咳嗽、咯痰、胸痛伴气促为主，病变多发生于较大的支气管。组织、细胞形态学见瘤细胞体积较大，核多形性明显。免疫组化示肺原发性ALCL表达T细胞抗原、CD30及ALK(+)。结论肺原发性ALCL非常罕见，其临床表现、影像学检查无特异性，容易误诊，而诊断需要依靠病理活检和免疫组化，该病预后较差。
目的 探討肺原髮性間變性大細胞淋巴瘤(anaplastic large cell lymphoma,ALCL)臨床病理特點、免疫組化特點、鑒彆診斷、治療和診斷技術，以提高對肺原髮性ALCL的認識。方法 通過本病例及複習相關的文獻資料，迴顧性分析病例的臨床特徵、組織細胞形態學和免疫組化特點。結果 肺原髮性ALCL的臨床特點以咳嗽、咯痰、胸痛伴氣促為主，病變多髮生于較大的支氣管。組織、細胞形態學見瘤細胞體積較大，覈多形性明顯。免疫組化示肺原髮性ALCL錶達T細胞抗原、CD30及ALK(+)。結論肺原髮性ALCL非常罕見，其臨床錶現、影像學檢查無特異性，容易誤診，而診斷需要依靠病理活檢和免疫組化，該病預後較差。
목적 탐토폐원발성간변성대세포림파류(anaplastic large cell lymphoma,ALCL)림상병리특점、면역조화특점、감별진단、치료화진단기술，이제고대폐원발성ALCL적인식。방법 통과본병례급복습상관적문헌자료，회고성분석병례적림상특정、조직세포형태학화면역조화특점。결과 폐원발성ALCL적림상특점이해수、각담、흉통반기촉위주，병변다발생우교대적지기관。조직、세포형태학견류세포체적교대，핵다형성명현。면역조화시폐원발성ALCL표체T세포항원、CD30급ALK(+)。결론폐원발성ALCL비상한견，기림상표현、영상학검사무특이성，용역오진，이진단수요의고병리활검화면역조화，해병예후교차。
Objective To investigate the clinical pathological features, immunohistochemical characteristics, differential diagnosis,treatment and diagnosis of primary pulmonary anaplastic larger cell lymphoma,so as to improve the understanding of this disease. Methods The clinical features,histiocygtic morphology and immunohistochemical characteristics of primary pulmonary anaplastic larger cell lymphoma were retrospectively analysed by studying one case and correlated literatures. Results Clinical features of primary pulmonary anaplastic larger cell lymphoma were mainly cough, sputum, chest pains combined with shortness of breath. The lesions often happened at larger bronchus. The malignant cells were obviously large and multinucleate. Primary pulmonary anaplastic larger cell lymphoma expressed Tcell antigens,CD30( + ) and ALK ( + ). Conclusions Primary pulmonary anaplastic larger cell lymphoma is very rare. Clinical manifestations and radiological images are nonspecific,it is easy to be misdiagnosed.Its diagnosis bases on histopathology and immunohistochemistry. The prognosis of this disease is poor.
