中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
7期
591-594
,共4页
盖海军%朱志启%吴景欢%黄庆军
蓋海軍%硃誌啟%吳景歡%黃慶軍
개해군%주지계%오경환%황경군
精神病治疗前期间%首发精神分裂症
精神病治療前期間%首髮精神分裂癥
정신병치료전기간%수발정신분렬증
Duration of untreated psychosis%First episode schizophrenia
目的 探讨首发精神分裂症患者精神病治疗前期间(duration of untreated psychosis,DUP)的影响因素及临床疗效和DUP的关系.方法 对912例首发精神分裂症患者的病案资料进行流行病学调查.收集患者的一般资料、临床诊断及临床疗效.参考精神分裂症首发症状评定量表评估患者的DUP.根据DUP的中位值将患者分为短DUP和长DUP2组.结果 短DUP与长DUP2组间婚姻比较差异具有显著性(P<0.05),其中未婚在短DUP组频数分布(63.7%)高于长DUP组(52.6%),差异具有显著性(λ2=5.990,P<0.05),离婚在短DUP组频数分布(0.6%)低于长DUP组(4.4%),差异具有显著性(λ2=15.079,P<0.01).精神分裂症单纯型在短DUP组频数分布(1.5%)低于长DUP组(4.1%),差异具有显著性(λ2=5.868,P<0.05).2组临床疗效间的比较差异具有显著性(λ2=36.093,P<0.01),2组临床疗效间Ridit分析显示差异有显著性(u=5.183,P<0.01).多因素Logistic回归分析发现婚姻、发病年龄和临床诊断对DUP有显著影响.结论 在首发精神分裂症患者中,婚姻、发病年龄和临床诊断对DUP有影响,DUP越长其临床疗效越差.
目的 探討首髮精神分裂癥患者精神病治療前期間(duration of untreated psychosis,DUP)的影響因素及臨床療效和DUP的關繫.方法 對912例首髮精神分裂癥患者的病案資料進行流行病學調查.收集患者的一般資料、臨床診斷及臨床療效.參攷精神分裂癥首髮癥狀評定量錶評估患者的DUP.根據DUP的中位值將患者分為短DUP和長DUP2組.結果 短DUP與長DUP2組間婚姻比較差異具有顯著性(P<0.05),其中未婚在短DUP組頻數分佈(63.7%)高于長DUP組(52.6%),差異具有顯著性(λ2=5.990,P<0.05),離婚在短DUP組頻數分佈(0.6%)低于長DUP組(4.4%),差異具有顯著性(λ2=15.079,P<0.01).精神分裂癥單純型在短DUP組頻數分佈(1.5%)低于長DUP組(4.1%),差異具有顯著性(λ2=5.868,P<0.05).2組臨床療效間的比較差異具有顯著性(λ2=36.093,P<0.01),2組臨床療效間Ridit分析顯示差異有顯著性(u=5.183,P<0.01).多因素Logistic迴歸分析髮現婚姻、髮病年齡和臨床診斷對DUP有顯著影響.結論 在首髮精神分裂癥患者中,婚姻、髮病年齡和臨床診斷對DUP有影響,DUP越長其臨床療效越差.
목적 탐토수발정신분렬증환자정신병치료전기간(duration of untreated psychosis,DUP)적영향인소급림상료효화DUP적관계.방법 대912례수발정신분렬증환자적병안자료진행류행병학조사.수집환자적일반자료、림상진단급림상료효.삼고정신분렬증수발증상평정량표평고환자적DUP.근거DUP적중위치장환자분위단DUP화장DUP2조.결과 단DUP여장DUP2조간혼인비교차이구유현저성(P<0.05),기중미혼재단DUP조빈수분포(63.7%)고우장DUP조(52.6%),차이구유현저성(λ2=5.990,P<0.05),리혼재단DUP조빈수분포(0.6%)저우장DUP조(4.4%),차이구유현저성(λ2=15.079,P<0.01).정신분렬증단순형재단DUP조빈수분포(1.5%)저우장DUP조(4.1%),차이구유현저성(λ2=5.868,P<0.05).2조림상료효간적비교차이구유현저성(λ2=36.093,P<0.01),2조림상료효간Ridit분석현시차이유현저성(u=5.183,P<0.01).다인소Logistic회귀분석발현혼인、발병년령화림상진단대DUP유현저영향.결론 재수발정신분렬증환자중,혼인、발병년령화림상진단대DUP유영향,DUP월장기림상료효월차.
Objective To explore the influencing factor of duration of untreated psychosis(DUP) and the relationship between duration of untreated psychosis and treatment outcome in epidemiological first-episode schizophrenia. Methods 912 medical records of the first episode schizophrenia patients were recruited in the study for epidemiological survey . The general medical data, clinical diagnosis, and treatment outcome were collected. DUP was determined refer to symptom onset for schizophrenia (SOS) scale. Patients were divided into short DUP and long DUP groups according to the median values of DUP values. Results Between short DUP and long DUP groups, the difference in marriage was significant ( P < 0. 05). The unmarried patients in the short DUP group (63.7% ) was higher than the long DUP group (52.6% ), the variance was significant (λ2 =5.990, P<0.05). The divorce in the short DUP group (0.6% ) was lower than the long DUP group (4.4% ) , the variance was significant (λ2 =5.079, P<0.01).The simple schizophrenia in the short DUP group (1.5%) was lower than the long DUP group (4. 1% ) , the variance was significant (λ2 =5.868, P<0.05). The treatment outcomes between the two groups had a significant variance ( λ2 =36.093, P < 0.01) , and the Ridit analysis of treatment outcomes between the two groups showed significant difference ( u = 5.183, P<0.01). The marriage,age of onset and clinical diagnosis were significantly correlated with DUP in multiple factor Logistic regression analysis. Conclusion The marriage,age of onset and clinical diagnosis are significantly correlated with DUP in the first episode schizophrenia patients,the longer of DUP and the worse of treatment outcome.
