CAJ | 학술논문

目的评价CA125和血管内皮生长因子(VEGF)作为预测非霍奇金淋巴瘤(NHL)患者骨髓浸润的血清学指标的价值.方法 97例经病理确诊的初治NHL患者,其中50例经骨髓活检或骨穿检查证实有骨髓浸润,46例骨髓正常者作为对照组.采用ELISA方法分别于化疗前检测血清CA125和VEGF水平.结果 97例NHL患者中,骨髓浸润者占51.5%(50例),骨髓正常者占45.5%(47例).有骨髓浸润组其血清CA125和VEGF水平明显高于无骨髓浸润组(P<0.05).VEGF水平与骨髓中肿瘤细胞所占百分比呈正相关(r=0.498,P=0.01),CA125水平与其无明显相关.结论 NHL骨髓浸润者血清CA125和VEGF明显升高,而且VEGF水平与骨髓浸润程度呈正相关.
목적 평개CA125화혈관내피생장인자(VEGF)작위예측비곽기금림파류(NHL)환자골수침윤적혈청학지표적개치.방법 97례경병리학진적초치NHL환자,기중50례경골수활검혹골천검사증실유골수침윤,46례골수정상자작위대조조.채용ELISA방법 분별우화료전검측혈청CA125화VEGF수평.결과 97례NHL환자중,골수침윤자점51.5%(50례),골수정상자점45.5%(47례).유골수침윤조기혈청CA125화VEGF수평명현고우무골수침윤조(P<0.05).VEGF수평여골수중종류세포소점백분비정정상관(r=0.498,P=0.01),CA125수평여기무명현상관.결론 NHL골수침윤자혈청CA125화VEGF명현승고,이차VEGF수평여골수침윤정도정정상관.
Objective To detect serum CA125 and VEGF in patients of non-Hodgkin lymophoma (NHL) involved in bone marrow and analyse prognostic criteria for NHL. Methods The clinical data of 97 patient were chosen as research objects. They were all first-visit patients. Bone marrow infiltrated with lymphoma cell leukemia of 50 patients were identified by bone marrow aspiration or bone marrow biopsy 46 cases of normal bone marrow were used as controls. The serum CA125 and VEGF were detected by ELISA before treatment. Results Among 97 cases of non-Hodgkin disease, there were 50 cases of bone marrow infiltrated lymphoma cells with a incidence rate of 51.5 %. CA125 and VEGF level in the patients whose bone marrow or lymphoma cell leukemia existed NHL cells was much higher than that of NHL with negative bone marrow infutration (P <0.05). Conclusion CA125 and VEGF can be concluded clinical markers which decide bone marrow or lymphoma cell leukem of the NHL patients whether existed NHL cells or not.