CAJ | 학술논문

目的了解吸烟量对β细胞功能的影响,并探讨中心型肥胖在吸烟量与β细胞功能关系中的中介效应.方法 2006-2007年在广州和珠海市参加慢性病筛查研究的社区居民中选择1440名吸烟者为研究对象,调查人口学特征和每天吸烟量,测量腰臀比,并检测空腹血清C肽浓度.结果控制混杂因素后,以每天吸烟1～10支者为对照组,每天吸烟11～20支者和＞20支者出现较高C肽浓度(大于中位数)的OR值分别为1.53(95%CI:1.22～1.90)和1.92(95%CI:1.32～2.79).吸烟量与中心型肥胖成正相关(a=0.21),并且控制了中心型肥胖的作用后(b=0.94),吸烟量与β细胞功能的关联仍然具有统计学意义(c'=0.33);中心型肥胖对吸烟量的中介效应值为37.54%.结论吸烟可能是β细胞功能受损的危险因素,并且中心型肥胖可能是二者关联中的一个部分中介因素.
목적 료해흡연량대β세포공능적영향,병탐토중심형비반재흡연량여β세포공능관계중적중개효응.방법 2006-2007년재엄주화주해시삼가만성병사사연구적사구거민중선택1440명흡연자위연구대상,조사인구학특정화매천흡연량,측량요둔비,병검측공복혈청C태농도.결과 공제혼잡인소후,이매천흡연1～10지자위대조조,매천흡연11～20지자화＞20지자출현교고C태농도(대우중위수)적OR치분별위1.53(95%CI:1.22～1.90)화1.92(95%CI:1.32～2.79).흡연량여중심형비반성정상관(a=0.21),병차공제료중심형비반적작용후(b=0.94),흡연량여β세포공능적관련잉연구유통계학의의(c'=0.33);중심형비반대흡연량적중개효응치위37.54%.결론 흡연가능시β세포공능수손적위험인소,병차중심형비반가능시이자관련중적일개부분중개인소.
Objective To confirm the effect of cigarette smoking on β-cell function, and further investigate the mediation effect of abdominal obesity. Methods Participants would include 1440 Chinese smokers who had participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. They were interviewed with structured questionnaire on their socio-demographic status and smoking behaviors. Waist-to-hip ratio (WHR) and fasting serum C-peptide concentration were also measured. Results After adjustment for the potential confounding factors, when compared with smokers with consumption 1-10 cigarettes/day, smokers with consumption of 11-20 cigarettes/day (adjusted OR=1.53, 95%CI: 1.22-1.90) or ＞20 cigarettes/day (adjusted OR=1.92, 95%CI: 1.32-2.79) had significant higher risks to get C-peptide concentration larger than its median. Furthermore, 37.54% of the effect of cigarette smoking on C-peptide concentration was partially mediated by abdominal obesity. Conclusion Cigarette smoking might be a risk factor for β-cell dysfunction and abdominal obesity.