中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2011年
3期
209-211
,共3页
马文敏%亓鹏%张建中%易勇%陈兴明%张军%韩瑞刚
馬文敏%亓鵬%張建中%易勇%陳興明%張軍%韓瑞剛
마문민%기붕%장건중%역용%진흥명%장군%한서강
噪声%凝血酶时间%凝血酶原时间%一氧化氮
譟聲%凝血酶時間%凝血酶原時間%一氧化氮
조성%응혈매시간%응혈매원시간%일양화담
Noise%Thrombin time%Prothrombin time%Nitric oxide
目的 研究16 Hz、120 dB,16 Hz、125 dB次声暴露后豚鼠凝血功能的变化规律,探讨次声造成生物体循环系统损害的机制.方法 将豚鼠分为对照组及16 Hz、120 dB,16 Hz、125 dB 2个暴露组,每个暴露组均按暴露时间再分成1、7、14、21 d 4个时间亚组,每个亚组8只豚鼠.各个暴露亚组每日暴露1.5 h,分别连续暴露相应的天数后抽取血样测定凝血功能相关指标及血清中一氧化氮(NO)含量.结果 16 Hz、125 dB组凝血酶原时间(PT)、国际标准化比率(INR)分别为(31.16±3.05)s和2.53±1.21,较对照组[(21.36±0.10)s、1.65±0.07]明显延长,差异有统计学意义(P＜0.05);血清中NO含量[(88.304±52.601)μmol/L]较对照组[(30.943±26.864)μmol/L]明显升高,差异有统计学意义(P＜0.05).16 Hz、125 dB组暴露14 d时PT和INR较对照组明显延长,并持续至第21天.16 Hz、125 dB组暴露7 d时血清中NO含量较对照组明显升高,且第14天继续升高,差异均有统计学意义(P＜0.05),21天时有下降趋势.结论 16 Hz、125 dB次声暴露后豚鼠凝血功能减退,INR及PT可做为评价次声对凝血功能影响的指标.
目的 研究16 Hz、120 dB,16 Hz、125 dB次聲暴露後豚鼠凝血功能的變化規律,探討次聲造成生物體循環繫統損害的機製.方法 將豚鼠分為對照組及16 Hz、120 dB,16 Hz、125 dB 2箇暴露組,每箇暴露組均按暴露時間再分成1、7、14、21 d 4箇時間亞組,每箇亞組8隻豚鼠.各箇暴露亞組每日暴露1.5 h,分彆連續暴露相應的天數後抽取血樣測定凝血功能相關指標及血清中一氧化氮(NO)含量.結果 16 Hz、125 dB組凝血酶原時間(PT)、國際標準化比率(INR)分彆為(31.16±3.05)s和2.53±1.21,較對照組[(21.36±0.10)s、1.65±0.07]明顯延長,差異有統計學意義(P＜0.05);血清中NO含量[(88.304±52.601)μmol/L]較對照組[(30.943±26.864)μmol/L]明顯升高,差異有統計學意義(P＜0.05).16 Hz、125 dB組暴露14 d時PT和INR較對照組明顯延長,併持續至第21天.16 Hz、125 dB組暴露7 d時血清中NO含量較對照組明顯升高,且第14天繼續升高,差異均有統計學意義(P＜0.05),21天時有下降趨勢.結論 16 Hz、125 dB次聲暴露後豚鼠凝血功能減退,INR及PT可做為評價次聲對凝血功能影響的指標.
목적 연구16 Hz、120 dB,16 Hz、125 dB차성폭로후돈서응혈공능적변화규률,탐토차성조성생물체순배계통손해적궤제.방법 장돈서분위대조조급16 Hz、120 dB,16 Hz、125 dB 2개폭로조,매개폭로조균안폭로시간재분성1、7、14、21 d 4개시간아조,매개아조8지돈서.각개폭로아조매일폭로1.5 h,분별련속폭로상응적천수후추취혈양측정응혈공능상관지표급혈청중일양화담(NO)함량.결과 16 Hz、125 dB조응혈매원시간(PT)、국제표준화비솔(INR)분별위(31.16±3.05)s화2.53±1.21,교대조조[(21.36±0.10)s、1.65±0.07]명현연장,차이유통계학의의(P＜0.05);혈청중NO함량[(88.304±52.601)μmol/L]교대조조[(30.943±26.864)μmol/L]명현승고,차이유통계학의의(P＜0.05).16 Hz、125 dB조폭로14 d시PT화INR교대조조명현연장,병지속지제21천.16 Hz、125 dB조폭로7 d시혈청중NO함량교대조조명현승고,차제14천계속승고,차이균유통계학의의(P＜0.05),21천시유하강추세.결론 16 Hz、125 dB차성폭로후돈서응혈공능감퇴,INR급PT가주위평개차성대응혈공능영향적지표.
Objective To study the change of the blood coagulation function of guinea pigs exposed to 16 Hz/120 dB, 16 Hz/125 dB infrasound and to explore the mechanism of circulation system damage.Methods Seventy-two guinea pigs were divided into 3 groups: the control group, the group exposed to 16 Hz/120 dB infrasound for 1.5 h a day and the group exposed to 16 Hz/125 dB infrasound for 1.5 h a day. Each exposure group was divided into 4 sub-groups (8 guinea pigs a sub-group) which were exposed to infrasound for 1, 7, 14 and 21 d, respectively. The coagulation function and serum nitric oxide (NO) were measured for control group and all sub-groups after exposure to infrasound. Results The prothrombin time (PT),international normalized ratio (INR) and serum NO of group exposed to 16 Hz/125 dB infrasound were (31.16±3.05) s, 2.53±1.21 and (88.304±52.601)μmol/L, respectively, which were significantly higher than those [(21.36±0.10) s, 1.65±0.07 and (30.943±26.864) μ mol[L] of control group (P＜0.05). PT and INR of sub-groups exposed to 16 Hz/125 dB infrasound for 14 and 21 d were significantly higher than those of control group. NO of sub-groups exposed to 16 Hz/125 dB infrasound for 1 week and 2 weeks were significantly higher than that of control group (P＜0.05), but NO of sub-group exposed to 16 Hz/125 dB infrasound for 3 weeks decreased slightly. Conclusion The blood coagulation function of guinea pigs exposed to 16 Hz/125 dB infrasound decreased, PT and INR may be used as the indexes to assess of blood coagulation function change induced by the infrasound exposure.
