CAJ | 학술논문

目的应用海德堡视网膜断层扫描仪(HRTⅡ)和光学相干断层扫描(optical coherence tomography,OCT),对初次进行胰岛素强化治疗的2型糖尿病患者黄斑区视网膜厚度进行评价.方法前瞻性病例研究.对40例初次进行胰岛索强化治疗的合并非增殖期糖尿病性视网膜病变的2型糖尿病患者,分别用HRTⅡ和OCT检查胰岛素强化治疗前,治疗后1月、3月和6月的黄斑区水肿指数e值和视网膜厚度变化并进行比较.结果黄斑区一环、二环和三环胰岛素强化治疗后1月、3月、6月的e值与强化治疗前比较均差异无统计学意义(P＞0.05)；黄斑区一环胰岛素强化治疗后1月、3月、6月OCT所测的视网膜厚度值分别与强化治疗前视网膜厚度值比较均差异无统计学意义(P＞0.05);二环强化治疗后1月OCT所测的视网膜厚度值与治疗前相比有统计学意义(P＝0.019),治疗后3月、6月与治疗前差异无统计学意义(P＞0.05)；三环胰岛素强化治疗后1月、3月OCT所测的视网膜厚度值与治疗前相比有统计学意义(分别为P =0.010、0.000,),治疗后6月与治疗前差异无统计学意义(P＞0.05).结论短期胰岛素强化治疗对合并非增殖期糖尿病视网膜病变的2型糖尿病性患者的黄斑厚度改变并无明显影响.
목적 응용해덕보시망막단층소묘의(HRTⅡ)화광학상간단층소묘(optical coherence tomography,OCT),대초차진행이도소강화치료적2형당뇨병환자황반구시망막후도진행평개.방법 전첨성병례연구.대40례초차진행이도색강화치료적합병비증식기당뇨병성시망막병변적2형당뇨병환자,분별용HRTⅡ화OCT검사이도소강화치료전,치료후1월、3월화6월적황반구수종지수e치화시망막후도변화병진행비교.결과 황반구일배、이배화삼배이도소강화치료후1월、3월、6월적e치여강화치료전비교균차이무통계학의의(P＞0.05)；황반구일배이도소강화치료후1월、3월、6월OCT소측적시망막후도치분별여강화치료전시망막후도치비교균차이무통계학의의(P＞0.05);이배강화치료후1월OCT소측적시망막후도치여치료전상비유통계학의의(P＝0.019),치료후3월、6월여치료전차이무통계학의의(P＞0.05)；삼배이도소강화치료후1월、3월OCT소측적시망막후도치여치료전상비유통계학의의(분별위P =0.010、0.000,),치료후6월여치료전차이무통계학의의(P＞0.05).결론 단기이도소강화치료대합병비증식기당뇨병시망막병변적2형당뇨병성환자적황반후도개변병무명현영향.
Objective To study the change of macular thickness after intensive insulin therapy by using Heidelberg retinal tomography Ⅱ (HRT Ⅱ) and optical coherence tomography (OCT).Methods This was a prospective case series study,80 eyes of 40 patients of type 2 diabetes mellitus with Non-Proliferative Diabetic Retinopathy (NPDR) under intensive insulin therapy were included into study.HRT Ⅱ was used to obtain the macular edema index (e-value) and the OCT was used to obtain the value of macular thickness.The follow times were at pre-treatment and 1 month,3months and 6 months after intensive insulin therapy.The repeated measurement and LSD pairwise comparison were used to analyze the data. Results The e-value and the macular thickness of the first-ring,the second-ring and the third-ring of macular area were analyzed respectively,the difference among the pre-treatment and 1 month,3 months and 6 months post-treatment had no statistically significant (P ＞ 0.05). Conclusions No significant change of macular thickness of type 2 diabetes mellitus with NPDR is observed after a short term intensive insulin therapy.