CAJ | 학술논문

46例川崎病患儿(观察组)根据超声心动图结果分为冠状动脉损伤(CAL)组19例和非冠状动脉损伤(NCAL)组27例,另选择正常健康者50例为对照组.检测所有对象的心型脂肪酸结合蛋白(h-FABP)、血小板活化因子(PAF)、肌钙蛋白Ⅰ及肌酸磷酸激酶同工酶等.结果显示,观察组h-FABP、肌钙蛋白Ⅰ水平和阳性率均显著高于对照组(P＜0.05),两组间肌酸磷酸激酶同工酶水平和阳性率比较差异无统计学意义(P＞0.05),观察组h-FABP阳性率显著高于肌钙蛋白Ⅰ和肌酸磷酸激酶同工酶阳性率(P＜0.05),PAF水平及血小板、中性粒细胞计数显著高于对照组(P＜0.05);CAL组h-FABP、PAF水平显著高于NCAL组(P＜0.05).提示,h-FABP和PAF对预测川崎病患儿冠状动脉病变有重要的临床价值.
46례천기병환인(관찰조)근거초성심동도결과분위관상동맥손상(CAL)조19례화비관상동맥손상(NCAL)조27례,령선택정상건강자50례위대조조.검측소유대상적심형지방산결합단백(h-FABP)、혈소판활화인자(PAF)、기개단백Ⅰ급기산린산격매동공매등.결과현시,관찰조h-FABP、기개단백Ⅰ수평화양성솔균현저고우대조조(P＜0.05),량조간기산린산격매동공매수평화양성솔비교차이무통계학의의(P＞0.05),관찰조h-FABP양성솔현저고우기개단백Ⅰ화기산린산격매동공매양성솔(P＜0.05),PAF수평급혈소판、중성립세포계수현저고우대조조(P＜0.05);CAL조h-FABP、PAF수평현저고우NCAL조(P＜0.05).제시,h-FABP화PAF대예측천기병환인관상동맥병변유중요적림상개치.
Forty six children with Kawasaki disease (observer group) were classified as coronary artery lesions (CAL) subgroup (19 cases) and non-coronary artery lesions (NCAL) subgroup (27 cases)according to echocardiography; 50 healthy children served as control group.Serum heart-type fatty acidbinding protein (h-FABP), platelet activating factor (PAF), cardiac tropnin Ⅰ (cTnI) and creatine kinase isoenzyme MB (CK-MB) levels of all subjects were detected.The results showed that the h-FABP and cTnI levels and positive rate in observer group were higher those in control group (P ＜ 0.05 ), while there were no differences in CK-MB level and positive rate between two groups ( P ＞ 0.05 ).The h-FABP positive rate in observation group was higher than the positive rates of cTnI and CK-MB (P ＜0.05).The PAF level, PLT and polymorphonuclear neutrophil count in observer group were higher than those in control group ( P ＜0.05).The h-FABP and PAF levels in CAL subgroup were higher than those in NCAL subgroup (P ＜0.05).The results suggest that serum h-FABP and PAF can be used as diagnostic indicators for Kawasaki disease complicated with coronary artery lesions.