CAJ | 학술논문

肿瘤局部存在多种类型的免疫抑制性细胞,其中调节性T细胞 (regulatory T cell,Treg)在肿瘤的发生、发展过程中发挥着极为重要的作用.Treg通过多种机制抑制免疫效应细胞的功能,是肿瘤免疫逃逸的关键因素.这些机制包括分泌抑制性细胞因子抑制效应细胞功能、分泌颗粒酶和穿孔素杀伤效应细胞、干扰效应细胞的代谢功能,以及通过调控树突状细胞影响Treg的分化和增殖,等等.Treg的深入研究为肿瘤免疫治疗提供了新的思路,以Treg及相关免疫抑制性分子作为靶点,通过特异性或非特异性清除Treg、控制Treg的数量和功能等开展肿瘤免疫治疗具有良好的临床应用前景.
종류국부존재다충류형적면역억제성세포,기중조절성T세포 (regulatory T cell,Treg)재종류적발생、발전과정중발휘착겁위중요적작용.Treg통과다충궤제억제면역효응세포적공능,시종류면역도일적관건인소.저사궤제포괄분비억제성세포인자억제효응세포공능、분비과립매화천공소살상효응세포、간우효응세포적대사공능,이급통과조공수돌상세포영향Treg적분화화증식,등등.Treg적심입연구위종류면역치료제공료신적사로,이Treg급상관면역억제성분자작위파점,통과특이성혹비특이성청제Treg、공제Treg적수량화공능등개전종류면역치료구유량호적림상응용전경.
There are multiple types of inhibitory immune cells in tumor. Among these cells, Treg (regulatory T cell) plays an extremely important role in tumor development and progression. Treg exihibits potent inhibitory effects on effector cells by a variety of mechanisms, which might be the the key factor for tumor immune escape. These mechanisms include inhibiting the effector cell function by inhibitory cytokines, killing effector cells by granzyme and profrin, interfering effector cell metabolism, and affecting Treg differentiation and proliferation by regulating the function of dendrtic cells, etc. The research on Treg has provided new strategies for tumor immunotherapy. Tumor immunotherapies targeting Treg and related immunosuppressive factors, such as deleting Treg nonsepcificlly or sepcificlly controling the numbers and functions of Treg, might have a bright future in clinical application.keyword regulatory T cell(Treg); neoplasms; immune escape; immunotherapy