CAJ | 학술논문

背景:尽管组织工程皮肤已应用于皮肤缺损的修复治疗,但远未达到完全代替永久性皮肤的程度.目的:探讨不同类型组织工程皮肤的生物学特性及其临床应用评价.方法:应用计算机检索Pubmed数据库(1990-01/2005-12),检索词为"tissue-engineered skin";应用计算机检索CNKI数据库(2002-01/2007-12),检索词为"组织工程皮肤". 结果与结论:计算机初检得到226篇文献,阅读标题和摘要进行初筛,排除因研究目的与此文无关或内容重复性的研究,共保留11篇文献进行分析.皮肤组织工程学目的是创建出组织学及功能特性上最接近人类皮肤组织的皮肤替代物,尽管目前已经有多种较为成熟的组织工程皮肤产品应用于临床,并且又研制了多种人工皮肤类型,但是它们大多数只是在结构上与人体皮肤类似,只具有皮肤的屏障功能,由于缺乏皮肤附件,所以它们并不具备完整的皮肤功能,并没有达到真正的皮肤重建.理想的皮肤替代物应具有表皮层和真皮层,真皮层可以快速的血管化和神经再分布,可促进快速的生理性的伤13修复;表皮层可以快速地获得充分的屏障和保护功能,与伤口创面充分一体化.一种良好的真皮载体除了应具备较好的组织相容性外,还必须具有一定的理化性能,如强度、柔软度、弹性、透气、透湿性能,才能保证真皮和创面贴附良好,为细胞生长提供理想的纤维支架,从而促进自体皮生长.组织工程皮肤应用前景良好,但目前在生物相容性、皮肤功能重建等方面仍存在各种问题需要解决.
배경:진관조직공정피부이응용우피부결손적수복치료,단원미체도완전대체영구성피부적정도.목적:탐토불동류형조직공정피부적생물학특성급기림상응용평개.방법:응용계산궤검색Pubmed수거고(1990-01/2005-12),검색사위"tissue-engineered skin";응용계산궤검색CNKI수거고(2002-01/2007-12),검색사위"조직공정피부". 결과여결론:계산궤초검득도226편문헌,열독표제화적요진행초사,배제인연구목적여차문무관혹내용중복성적연구,공보류11편문헌진행분석.피부조직공정학목적시창건출조직학급공능특성상최접근인류피부조직적피부체대물,진관목전이경유다충교위성숙적조직공정피부산품응용우림상,병차우연제료다충인공피부류형,단시타문대다수지시재결구상여인체피부유사,지구유피부적병장공능,유우결핍피부부건,소이타문병불구비완정적피부공능,병몰유체도진정적피부중건.이상적피부체대물응구유표피층화진피층,진피층가이쾌속적혈관화화신경재분포,가촉진쾌속적생이성적상13수복;표피층가이쾌속지획득충분적병장화보호공능,여상구창면충분일체화.일충량호적진피재체제료응구비교호적조직상용성외,환필수구유일정적이화성능,여강도、유연도、탄성、투기、투습성능,재능보증진피화창면첩부량호,위세포생장제공이상적섬유지가,종이촉진자체피생장.조직공정피부응용전경량호,단목전재생물상용성、피부공능중건등방면잉존재각충문제수요해결.
BACKGROUND:Tissue engineered skin has been used to repair defect skin, but it is not as good as to completely replace permanent skin. OBJECTIVE: To explore the biological characteristics and clinical application of various types of tissue engineered skin. METHODS: Pubmed data (1990-01/2005-12) was retrieved by computer with the key words of "tissue-engineered skin". CNKI database (2002-01/2007-12) was retrieved with the same key words. RESULTS AND CONCLUSION: Totally 226 literatures were primarily selected. After reading titles and Abstracts, studies addressing irrelative objective or repetitive content were excluded, and 11 literatures were included. The aim of skin tissue engineering is to create skin substitute that close to human.skin in histology and functional characteristics. There were many mature tissue engineered skin in clinic, and various artificial skins were developed. Their structure was similar to human, but only had skin barrier function and lack of skin appendages, so they did not have complete skin function, and did not reach skin reestablishment. Ideal skin substitute should process cuticular layer and dermial layer. The dermial layer can reach rapid vascularization and nerve redistribution, can promote physiological wound repair. The cuticular layer can rapidly obtain full barrier and protection function, which can be fully integration with wound surface. A good dermial carrier has good histocompatibility, and a certain physical and chemical properties, such as strength, scratchability, elasticity, gas permeation, water vapor permeability. These can provide a good adherence between dermis and wound surface, offer an ideal fiber stent for cell growth, and finally promote autologous skin growth. Tissue engineered skin has good prospect, but there are many problems that should be solved in biocompatibility and skin function reestablishment.