国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2011年
3期
230-232,240
,共4页
宫颈非典型增生%细胞学%乳头状瘤病毒感染%生物学标记
宮頸非典型增生%細胞學%乳頭狀瘤病毒感染%生物學標記
궁경비전형증생%세포학%유두상류병독감염%생물학표기
Uterine cervical dysplasia%Cytology%Papillomatirus infections%Biological markers
重复细胞学检查、人乳头瘤病毒(HPV)检测或立即阴道镜为当前处理不明确意义不典型鳞状上皮细胞(ASCUS)最常用的方法.但这3种方法存在高漏诊率和误诊率、主观性强等不足,HPV持续感染、整合感染、宿主细胞基因不稳定及细胞恶性转变的生物学标记可更客观、有效地分流ASCUS.基于生物标记的多参数立体化检测可能成为分流异常细胞学结果的主要模式和手段.
重複細胞學檢查、人乳頭瘤病毒(HPV)檢測或立即陰道鏡為噹前處理不明確意義不典型鱗狀上皮細胞(ASCUS)最常用的方法.但這3種方法存在高漏診率和誤診率、主觀性彊等不足,HPV持續感染、整閤感染、宿主細胞基因不穩定及細胞噁性轉變的生物學標記可更客觀、有效地分流ASCUS.基于生物標記的多參數立體化檢測可能成為分流異常細胞學結果的主要模式和手段.
중복세포학검사、인유두류병독(HPV)검측혹립즉음도경위당전처리불명학의의불전형린상상피세포(ASCUS)최상용적방법.단저3충방법존재고루진솔화오진솔、주관성강등불족,HPV지속감염、정합감염、숙주세포기인불은정급세포악성전변적생물학표기가경객관、유효지분류ASCUS.기우생물표기적다삼수입체화검측가능성위분류이상세포학결과적주요모식화수단.
Repeat cervical cytologic testing,human papillomavirus(HPV)testing and immediate colposcopy are currently the most general managements in women with atypical squamous cells of undetermined significance(ASCUS)result.However,the efficacy of these three methods is hampered by strong subjectivity,high false negative and positive rates.With the development of the aetiology of cervical cancer,there is good evidence that biomarkers for persistent HPV infection,HPV integration,instability of host genes and malignancy triage ASCUS more objectively and efficiently.The three-dimensional multiparameter biomarker-based detection may be the predominant method for the triage of women with abnormal cervical cancer screening result.