CAJ | 학술논문

目的观察草分枝杆菌F.U.36注射液对尖锐湿疣电灼术后的临床疗效以及对机体免疫功能的影响.方法 105例尖锐湿疣患者经电灼术后随机分为治疗组(草分枝杆菌,55例)和对照组(α-2b干扰素,50例),8周为1个疗程,观察两组疗效以及外周血T细胞亚群改变情况.结果治疗组与对照组治愈率分别为47.3%、24.0%(P＜0.05),复发率分别为11.5%、41.7%(P＜0.05);治疗后两组CD+3、CD+4、CD+4/CD+8均升高,而CD+8降低,经统计学分析,治疗后两组CD+3、CD+4、CD+4/CD+8比较差异有统计学意义(P＜0.05),而CD+8比较差异无统计学意义(P＞0.05).结论草分枝杆菌注射液对防止尖锐湿疣复发具有一定作用,对患者免疫功能的提高优于α-2b干扰素.
목적 관찰초분지간균F.U.36주사액대첨예습우전작술후적림상료효이급대궤체면역공능적영향.방법 105례첨예습우환자경전작술후수궤분위치료조(초분지간균,55례)화대조조(α-2b간우소,50례),8주위1개료정,관찰량조료효이급외주혈T세포아군개변정황.결과 치료조여대조조치유솔분별위47.3%、24.0%(P＜0.05),복발솔분별위11.5%、41.7%(P＜0.05);치료후량조CD+3、CD+4、CD+4/CD+8균승고,이CD+8강저,경통계학분석,치료후량조CD+3、CD+4、CD+4/CD+8비교차이유통계학의의(P＜0.05),이CD+8비교차이무통계학의의(P＞0.05).결론 초분지간균주사액대방지첨예습우복발구유일정작용,대환자면역공능적제고우우α-2b간우소.
Objective To observe the curative effect of condyloma acuminatum patients treated with differences of bacilli phlei injection after fulfufized and the effect of immunity function. Methods We compared curative effect and peripheral blood T lymphocyte subpopulation in the treatment group( 55 cases, 8 weeks, prior and posttreatment with differences of bacilli phlei only) and the control group (50 cases, 8 weeks, prior and post-treatment with recombinant human interferon α-2b only). Results Compared with the control group (24.0 %/41.7 % ), the treatment group(47.3 %/11.5 % ) had advantage in the terms of cure rate and relapse rate( P＜0.05 ). CD+3, CD+4 ,CD4+/CD+8 increased and CD+8 decreased in two groups after treatment. CD+3 , CD+4, CD+4/CDs+ were significantly increased in treatment group compared with the control group after treatment(P＜0.05), but CD+8 had no obvious difference in two groups(P＞0.05). Conclusion Differences of bacilli phlei injection can prevent relapse of condyloma acuminatum and increase immunity function of patients.