中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
24期
3-5
,共3页
子宫内膜肿瘤%血管内皮生长因子类%免疫组织化学
子宮內膜腫瘤%血管內皮生長因子類%免疫組織化學
자궁내막종류%혈관내피생장인자류%면역조직화학
Endometrial neoplasms%Vascular endothelial growth factors%Immunohistochemistry
目的 观察子宫内膜样腺癌组织中Maspin、血管内皮生长因子(VEGF)的表达.方法 采用免疫组织化学SP法检测49例子宫内膜样腺癌、12例子宫内膜不典型增生及15例正常子宫内膜组织中的Maspin和VEGF表达情况.结果 Maspin在正常子宫内膜组织中未见表达,在子宫内膜不典型增生组织(41.7%,5/12)和子宫内膜样腺癌组织(59.2%,29/49)中阳性表达率逐渐增高(P＜0.01),VEGF在正常子宫内膜组织(13.3%,2/15)、子宫内膜不典型增生组织(33.3%,4/12)和子宫内膜样腺癌组织(67.3%,33/49)中阳性表达率逐渐增高(P＜0.01);Maspin表达与子宫内膜样腺癌的FIGO分期有关(P=0.034),VEGF表达与子宫内膜样腺癌的肌层浸润深度有关(P=0.036);Maspin与VEGF的表达呈正相关(r=0.307,P＜0.05).结论 Maspin、VEGF与子宫内膜样腺癌的发展、侵袭相关,二者的异常表达共同作用促进子宫内膜样腺癌的发展和侵袭.
目的 觀察子宮內膜樣腺癌組織中Maspin、血管內皮生長因子(VEGF)的錶達.方法 採用免疫組織化學SP法檢測49例子宮內膜樣腺癌、12例子宮內膜不典型增生及15例正常子宮內膜組織中的Maspin和VEGF錶達情況.結果 Maspin在正常子宮內膜組織中未見錶達,在子宮內膜不典型增生組織(41.7%,5/12)和子宮內膜樣腺癌組織(59.2%,29/49)中暘性錶達率逐漸增高(P＜0.01),VEGF在正常子宮內膜組織(13.3%,2/15)、子宮內膜不典型增生組織(33.3%,4/12)和子宮內膜樣腺癌組織(67.3%,33/49)中暘性錶達率逐漸增高(P＜0.01);Maspin錶達與子宮內膜樣腺癌的FIGO分期有關(P=0.034),VEGF錶達與子宮內膜樣腺癌的肌層浸潤深度有關(P=0.036);Maspin與VEGF的錶達呈正相關(r=0.307,P＜0.05).結論 Maspin、VEGF與子宮內膜樣腺癌的髮展、侵襲相關,二者的異常錶達共同作用促進子宮內膜樣腺癌的髮展和侵襲.
목적 관찰자궁내막양선암조직중Maspin、혈관내피생장인자(VEGF)적표체.방법 채용면역조직화학SP법검측49례자궁내막양선암、12례자궁내막불전형증생급15례정상자궁내막조직중적Maspin화VEGF표체정황.결과 Maspin재정상자궁내막조직중미견표체,재자궁내막불전형증생조직(41.7%,5/12)화자궁내막양선암조직(59.2%,29/49)중양성표체솔축점증고(P＜0.01),VEGF재정상자궁내막조직(13.3%,2/15)、자궁내막불전형증생조직(33.3%,4/12)화자궁내막양선암조직(67.3%,33/49)중양성표체솔축점증고(P＜0.01);Maspin표체여자궁내막양선암적FIGO분기유관(P=0.034),VEGF표체여자궁내막양선암적기층침윤심도유관(P=0.036);Maspin여VEGF적표체정정상관(r=0.307,P＜0.05).결론 Maspin、VEGF여자궁내막양선암적발전、침습상관,이자적이상표체공동작용촉진자궁내막양선암적발전화침습.
Objective To analyze the expression and clinical significance of Maspin, vascular endothelial growth factor (VEGF) in endometrioid adenocarcinoma tissue samples. Methods Forty-nine cases of endometrioid adenocarcinoma, 12 cases of atypical hyperplasia of endometrium and 15 cases of normal endometrium were selected. Immunohistochemistry was used to study the expression of Maspin,as well as VEGF. Results The expression of Maspin was none in normal endometrium,while the positive rates of Maspin in atypical hyperplasia of endometrium (41.7％, 5/12 ) and endometrioid adenocarcinoma (59.2％,29/49) were ascending, there was statistical significance among the three groups (P＜0.01 ). The positive rates of VEGF in normal endometrium ( 13.3％, 2/15 ), atypical hyperplasia of endometrium ( 33.3％, 4/12 ),endometrioid adenocarcinoma (67.3％ ,33/49) also were ascending (P＜ 0.01 ). The expression of Maspin was related with the FIGO stage in endometrioid adenocarcinoma (P=0.034), and the expression of VEGF was related with the myometrial invasion(P = 0.036). There was positve correlation between the expression of Maspin and VEGF (r = 0.307,P＜0.05). Conclusions The expression of Maspin, VEGF in tumor tissue has a significant correlation with the level of invasion of endometrioid adenocarcinoma. The expressions of Maspin,VEGF apparently play an essential role in the development and invasion of endometrioid adenocarcinoma.
