国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2010年
1期
66-69
,共4页
姜远旭%袁世荧%尚游%丁泽君%乔瑞冬
薑遠旭%袁世熒%尚遊%丁澤君%喬瑞鼕
강원욱%원세형%상유%정택군%교서동
糖原合成酶激酶-3%炎症%危重病
糖原閤成酶激酶-3%炎癥%危重病
당원합성매격매-3%염증%위중병
Glycogen synthase kinase-3%Inflammation%Critical diseases
糖原合成酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)是细胞中广泛存在的丝氨酸/苏氨酸蛋白激酶,参与糖原的代谢,细胞内信号的转导,基因的转录和翻译;调节多种细胞激活、分化和生存.近年来发现,GSK-3β抑制剂在肺损伤、缺血/再灌注损伤、胰腺炎、脑损伤等危重病巾发挥抗炎作用,因此,抑制GSK-3β可能为治疗这些危重病提供一条新的途径.
糖原閤成酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)是細胞中廣汎存在的絲氨痠/囌氨痠蛋白激酶,參與糖原的代謝,細胞內信號的轉導,基因的轉錄和翻譯;調節多種細胞激活、分化和生存.近年來髮現,GSK-3β抑製劑在肺損傷、缺血/再灌註損傷、胰腺炎、腦損傷等危重病巾髮揮抗炎作用,因此,抑製GSK-3β可能為治療這些危重病提供一條新的途徑.
당원합성매격매-3β(glycogen synthase kinase-3β,GSK-3β)시세포중엄범존재적사안산/소안산단백격매,삼여당원적대사,세포내신호적전도,기인적전록화번역;조절다충세포격활、분화화생존.근년래발현,GSK-3β억제제재폐손상、결혈/재관주손상、이선염、뇌손상등위중병건발휘항염작용,인차,억제GSK-3β가능위치료저사위중병제공일조신적도경.
Glycogen synthase kinase-3β (GSK-3β) is a ubiquitous serine-threonine protein kinase involved in glycogen metabolism, cell membrane to nucleus signal transducting,gene transcription and translation, and the regulation of many cell activation, division and survival.Recent findings has showed that inhibitors of GSK-3βhad anti-inflammatory effects on acute lung injury, ischemia reperfusion injury,acute pancreatifis,brain injury and so on.Consequently, inhibition of GSK-3βactivity may provide a novel therapeutic approach to the management of critical diseases.
