CAJ | 학술논문

PET可从分子水平观察细胞生物学行为。目前，临床上最常用的葡萄糖代谢显像剂是18F-FDG，而最常用的细胞增殖显像剂是3’-脱氧-3’-18F-氟胸腺嘧啶(18F-FLT)。这两种显像剂在肿瘤的诊断和分期方面已有深入广泛的研究，而在治疗后疗效评价方面的研究近年也很受重视，特别是肿瘤在放化疗前后对18F-FDG和18F-FLT摄取值的变化与肿瘤体积及细胞增殖和细胞周期之间的关系。该文就18F-FDG和18F-FLT在肿瘤放化疗疗效评价中的实验研究进行综述。
PET가종분자수평관찰세포생물학행위。목전，림상상최상용적포도당대사현상제시18F-FDG，이최상용적세포증식현상제시3’-탈양-3’-18F-불흉선밀정(18F-FLT)。저량충현상제재종류적진단화분기방면이유심입엄범적연구，이재치료후료효평개방면적연구근년야흔수중시，특별시종류재방화료전후대18F-FDG화18F-FLT섭취치적변화여종류체적급세포증식화세포주기지간적관계。해문취18F-FDG화18F-FLT재종류방화료료효평개중적실험연구진행종술。
PET can observe the biological behavior of cell at the molecular level.18F-FDG is the most widely used glucose metabolic imaging agent.3'-Deoxy-3'-[18F]fluorothymidine (18F-FLT) is the most commonly used cell proliferation imaging agent.They both have been deeply researched in the diagnosis and staging of tumor.In recent years, researchers have paid more attention to monitoring the outcome of tumor therapy, especially to the relation between the uptake value variation of 18F-FDG, 18F-FLT before and during radiochemotherapy and tumor volume, cell proliferation, and cell cycle.This article was a research summary of the assessment of 18F-FDG and 18F-FLT in the outcome of cancer chemotherapy.