CAJ | 학술논문

目的评价奥拉西坦胶囊联合尼莫地平治疗血管性痴呆的疗效及安全性.方法将120例血管性痴呆患者完全随机分为联合治疗组和奥拉西坦组、尼莫地平组,各40例.在治疗前和治疗6个月后进行简易智力状态量表(MMSE)和日常生活能力量表(ADL)的评分,并对3组进行统计学分析.结果 3组治疗后MMSE及ADL评分均有明显改善(P＜0.05).治疗后MMSE评分比较,联合治疗组[(20.8±4.2)分]与尼莫地平组[(17.4±3.2)分]比较差异有统计学意义[(20.8±4.2)分比(17.4±3.2)分,P＜0.01],奥拉西坦组[(19.7±4.7)分]与尼莫地平组[(17.4±3.2)分]比较差异有统计学意义(P＜0.05)；治疗后ADL评分比较,联合治疗组与尼莫地平组和奥拉西坦组比较差异有统计学意义[(58.2±1.6)分比(53.3±11.2)分、(55.3±4.2)分,P＜0.01或P＜0.05].用药期间,2组不良反应轻微,均无死亡和恶性不良事件发生.结论奥拉西坦胶囊联合尼莫地平治疗血管性痴呆可明显改善血管性痴、呆患者的认知障碍和生活能力,安全性好.
목적 평개오랍서탄효낭연합니막지평치료혈관성치태적료효급안전성.방법 장120례혈관성치태환자완전수궤분위연합치료조화오랍서탄조、니막지평조,각40례.재치료전화치료6개월후진행간역지력상태량표(MMSE)화일상생활능역량표(ADL)적평분,병대3조진행통계학분석.결과 3조치료후MMSE급ADL평분균유명현개선(P＜0.05).치료후MMSE평분비교,연합치료조[(20.8±4.2)분]여니막지평조[(17.4±3.2)분]비교차이유통계학의의[(20.8±4.2)분비(17.4±3.2)분,P＜0.01],오랍서탄조[(19.7±4.7)분]여니막지평조[(17.4±3.2)분]비교차이유통계학의의(P＜0.05)；치료후ADL평분비교,연합치료조여니막지평조화오랍서탄조비교차이유통계학의의[(58.2±1.6)분비(53.3±11.2)분、(55.3±4.2)분,P＜0.01혹P＜0.05].용약기간,2조불량반응경미,균무사망화악성불량사건발생.결론 오랍서탄효낭연합니막지평치료혈관성치태가명현개선혈관성치、태환자적인지장애화생활능력,안전성호.
Objective To evaluate the clinical efficacy and safety of oxiracetam capsules and nimodipine in patients with vascular dementia by taking.Methods One hundred and twenty patients with vascular dementia were randomly divided into treatment group:oxiracetam group and nimodipine group.Before treatment and 6 months after treatment,Mini-Mental State Examination (MMSE) and Activities of Daily living scale (ADL) were used to assess the therapeutic effect.Results MMSE and ADL scores of 3 groups after treatment were all significantly improved ( P ＜ 0.05).After treatment,the MMSE scores in combined treatment group and nimodipine group had a significant difference [ (20.8 ± 4.2)scores vs ( 17.4 ± 3.2)scores,P ＜ 0.01 ] ; the difference in oxiracetam group and nimodipine group was statistically significant[ ( 19.7 ± 4.7) scores vs ( 17.4 ± 3.2) scores,P ＜ 0.05 ] ; after the treatment,ADL score in combined treatment group,nimodipine group and oxiracetam group difference had statistical significances [ (58.2 ± 1.6) scores vs (53.3 ± 11.2) scores,(55.3 ± 4.2) scores,P ＜ 0.01 or P ＜ 0.05 ].Conclusion Compared with taking nimodipine,patients with vascular dementia who take oxiracetam capsules and nimodipine can significantly improve mental retardation and living skills.