CAJ | 학술논문

目的观察非糖尿病人群血清补体C3、超敏C反应蛋白(hs-CRP)水平及其与胰岛素抵抗的关系.方法纳入587例非糖尿病个体,测定体重、身高、血压、腰围、空腹血浆葡萄糖、血清胰岛素、血脂、补体C3及hs-CRP等,计算胰岛素抵抗指数(HOMA2-IR).以HOMA2-IR上四分位为切点划分胰岛素抵抗与非胰岛素抵抗.结果胰岛素抵抗人群补体C3和hs-CRP显著高于非胰岛素抵抗人群.校正性别、年龄、BMI及腰围后,部分相关分析发现补体C3与HOMA2-IR显著正相关(r=0.19,P＜0.01).去除性别、年龄、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和腰围的影响后,随着补体C3的升高发生胰岛素抵抗的危险增加3.78倍(OR=3.78,P＜0.05);而hs-CRP与胰岛素抵抗的发生无统计学意义.结论在非糖尿病人群中,补体C3与胰岛素抵抗的相关性强于hs-CRP.
목적 관찰비당뇨병인군혈청보체C3、초민C반응단백(hs-CRP)수평급기여이도소저항적관계.방법 납입587례비당뇨병개체,측정체중、신고、혈압、요위、공복혈장포도당、혈청이도소、혈지、보체C3급hs-CRP등,계산이도소저항지수(HOMA2-IR).이HOMA2-IR상사분위위절점화분이도소저항여비이도소저항.결과 이도소저항인군보체C3화hs-CRP현저고우비이도소저항인군.교정성별、년령、BMI급요위후,부분상관분석발현보체C3여HOMA2-IR현저정상관(r=0.19,P＜0.01).거제성별、년령、수축압、서장압、총담고순、감유삼지、고밀도지단백담고순화요위적영향후,수착보체C3적승고발생이도소저항적위험증가3.78배(OR=3.78,P＜0.05);이hs-CRP여이도소저항적발생무통계학의의.결론 재비당뇨병인군중,보체C3여이도소저항적상관성강우hs-CRP.
Objective To observe and compare the association of serum levels of of complement component 3(C3)and high-sensitive C-reactive protein(hs-CRP)with insulin resistance in non-diabetic subjects. Methods 587non-diabetic Chinese were recruited. Weight, height, blood pressure, waist circumference, fasting plasma glucose,fasting serum insulin, blood lipids, C3 and hs-CRP were measured. HOMA index(HOMA2-IR)was calculated.Insulin resistance was defined as the upper quartile of HOMA2-IR. Results C3 and hs-CRP were significantly higher in subjects with insulin resistance compared with subjects without insulin resistance. After controlling for age, gender,body mass index, and waist circumference, C3 was positively and significantly correlated with HOMA2-IR(r = 0.19,P＜0.01). As C3 increased, subjects were 3.78(OR= 3.78, P＜0.05)times more likely to suffer from insulin resistance, after adjustment for age, gender, systolic blood pressure, diastolic blood pressure, total cholesterol,triglycerides,high-density lipoprotein cholesterol, and waist circumference. However, hs-CRP was not significantly correlated with insulin resistance. Conclusions Serum complement component 3 has a more marked association with insulin resistance than hs-CRP in non-diabetic Chinese.