中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
4期
296-300
,共5页
邓红珠%杜敏联%李燕虹%苏喆%马华梅%陈红珊
鄧紅珠%杜敏聯%李燕虹%囌喆%馬華梅%陳紅珊
산홍주%두민련%리연홍%소철%마화매%진홍산
生长追赶%胰岛素抵抗%小于胎龄儿
生長追趕%胰島素牴抗%小于胎齡兒
생장추간%이도소저항%소우태령인
Catch-up growth%Insulin resistance%Small for gestational age
目的 探讨小于胎龄儿(small for gestational age,SGA)出生后生长追赶状态与血清胰岛素水平的关系.方法 青春前期30例有生长追赶SGA(catch-up growth SGA,CUG-SGA组)、37例无生长追赶SGA(NCUG-SGA组)和42例适于胎龄儿(appropriate for gestational age,AGA组),测定空腹血糖、空腹胰岛素(FINS)和血清胰岛素样生长因子I(IGF-I).结果 (1)与NCUG-SGA和AGA组比较,CUG-SGA组FINS和稳态模型评估的胰岛素抵抗指数(HOMA-IR)显著为高(P<0.01或P<0.05),而NCUG-SGA组与AGA组则无显著性差异(P>0.05).CUG-SGA组血清IGF-I水平较NCUG-SGA组显著为高[(212.61±17.81对137.40±14.66)ng/ml,P=0.001],但与AGA组无显著性差异(P=0.095).(2)SGA组HOMA-IR与年龄、身高标准差分值增值(AHtSDS)和体重指数分别正相关;≤6岁SGA组FINS与△HtSDS呈正相关,>6岁组FINS与体重标准差分值增值呈正相关.结论 生后早期胰岛素可能以生长因子角色参与了SGA儿的生长追赶;胰岛素抵抗程度与生长追赶程度相随.
目的 探討小于胎齡兒(small for gestational age,SGA)齣生後生長追趕狀態與血清胰島素水平的關繫.方法 青春前期30例有生長追趕SGA(catch-up growth SGA,CUG-SGA組)、37例無生長追趕SGA(NCUG-SGA組)和42例適于胎齡兒(appropriate for gestational age,AGA組),測定空腹血糖、空腹胰島素(FINS)和血清胰島素樣生長因子I(IGF-I).結果 (1)與NCUG-SGA和AGA組比較,CUG-SGA組FINS和穩態模型評估的胰島素牴抗指數(HOMA-IR)顯著為高(P<0.01或P<0.05),而NCUG-SGA組與AGA組則無顯著性差異(P>0.05).CUG-SGA組血清IGF-I水平較NCUG-SGA組顯著為高[(212.61±17.81對137.40±14.66)ng/ml,P=0.001],但與AGA組無顯著性差異(P=0.095).(2)SGA組HOMA-IR與年齡、身高標準差分值增值(AHtSDS)和體重指數分彆正相關;≤6歲SGA組FINS與△HtSDS呈正相關,>6歲組FINS與體重標準差分值增值呈正相關.結論 生後早期胰島素可能以生長因子角色參與瞭SGA兒的生長追趕;胰島素牴抗程度與生長追趕程度相隨.
목적 탐토소우태령인(small for gestational age,SGA)출생후생장추간상태여혈청이도소수평적관계.방법 청춘전기30례유생장추간SGA(catch-up growth SGA,CUG-SGA조)、37례무생장추간SGA(NCUG-SGA조)화42례괄우태령인(appropriate for gestational age,AGA조),측정공복혈당、공복이도소(FINS)화혈청이도소양생장인자I(IGF-I).결과 (1)여NCUG-SGA화AGA조비교,CUG-SGA조FINS화은태모형평고적이도소저항지수(HOMA-IR)현저위고(P<0.01혹P<0.05),이NCUG-SGA조여AGA조칙무현저성차이(P>0.05).CUG-SGA조혈청IGF-I수평교NCUG-SGA조현저위고[(212.61±17.81대137.40±14.66)ng/ml,P=0.001],단여AGA조무현저성차이(P=0.095).(2)SGA조HOMA-IR여년령、신고표준차분치증치(AHtSDS)화체중지수분별정상관;≤6세SGA조FINS여△HtSDS정정상관,>6세조FINS여체중표준차분치증치정정상관.결론 생후조기이도소가능이생장인자각색삼여료SGA인적생장추간;이도소저항정도여생장추간정도상수.
Objective To evaluate the association between two different linear growth patterns with the levels of serum insulin in children bem small for gestational age(SGA).Methods Serum fasting glucose,fasting insulin,and insulin-like growth factor-I(IGF-I)concentrations were determined in 30 catch-up growth(CUG)children bern SGA [CUG-SGA,16 females,14males,(6.62±0.66)year],37 non-catch-up growth(NCUG)children born SGA[NCUG-SGA,15 females,22 males,(5.97±0.56)year],and42 appropriate for gestational age(AGA)children with normal height[AGA,16females,26males,(7.05±0.39)year].Results (1) Basal fasting insulin and homeostasis model assessment for insulin resistance(HOMA-IR)were significantly higher in CUG-SGA group than in NCUG-SGA and AGA group(P<0.01 or P<0.05).But there was no difference in fasting insulin between NCUG-SGA group and AGA group.IGF-I levels in CUG-SGA were significantly higher than in NCUG-SGA group[(212.61±17.81 vs 137.40±14.66)ng/ml,P=0.001],but showed no difference from AGA group(P=0.095).(2)In the SGA group,HOMA-IR showed positive correlation with age,△height SDS,and current body mass index.Fasting insulin showed positive correlation with △height SDS(r=0.500,P=0.002)in≤6 year group as well as with △weight SDS(r=0.496,P=0.030)in>6 year group.Conclusions Insulin as a growth factor may participate in postnatal catch-up growth accompanied with increased insulin resistance in SGA children.
