中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2008年
12期
1552-1554
,共3页
时京%孔垂泽%冯宗承%刘金秀%刘贤奎%刘涛%崔军%张辉%郑伟%李付彪
時京%孔垂澤%馮宗承%劉金秀%劉賢奎%劉濤%崔軍%張輝%鄭偉%李付彪
시경%공수택%풍종승%류금수%류현규%류도%최군%장휘%정위%리부표
前列腺肿瘤%前列腺增生%抗原%鉴别诊断
前列腺腫瘤%前列腺增生%抗原%鑒彆診斷
전렬선종류%전렬선증생%항원%감별진단
Prostate neplasms%Prostate hyperplasia%Antigen%Differential diagnosis
目的 探讨前列腺特异性抗原相关指标检测在前列腺癌(PCa)与良性前列腺增生(BPH)鉴别诊断中的作用.方法 对5家医院107例PCa患者和319例BPH患者的血清总前列腺特异性抗原(t-PSA)、游离前列腺特异性抗原(f-PSA)、结合前列腺特异性抗原(c-PSA)、f-PSA/t-PSA和c-PSA/t-PSA的差异进行分析比较.结果 PCa和BPH患者中,血清t-PSA处于4～20 μw,/L区间者分别达到68.2%和32.9%.血清t-PSA、f-PSA和c-PSA以及f-PSA/t-PSA和c-PSA/t-PSA在PCa组和BPH组之间差异均有统计学意义(P<0.05).只有f-PSA/t-PSA和c-PSA/t-PSA在PCa和BPH组内各年龄组之间差异无统计学意义(P>0.05),结果相对稳定.血清t-PSA在4-20μg/L区间时,以f-PSA/t-PSA<0.16作为诊断PCa的指标,诊断PCa的敏感度、特异度、阳性预测值和阴性预测值分别是89.0%、78.0%、60.7%和94.6%,以c-PSA/t-PSA>0.84作为诊断PCa的指标时,分别是91.8%、81.3%、66.3%和96.1%.结论 PCa和BPH患者血清t-PSA在4～20μg/L区间存在较大重叠.在此区间,f-PSA/t-PSA<0.16和c-PSA/t-PSA>0.84可作为诊断PCa较为理想的标准.
目的 探討前列腺特異性抗原相關指標檢測在前列腺癌(PCa)與良性前列腺增生(BPH)鑒彆診斷中的作用.方法 對5傢醫院107例PCa患者和319例BPH患者的血清總前列腺特異性抗原(t-PSA)、遊離前列腺特異性抗原(f-PSA)、結閤前列腺特異性抗原(c-PSA)、f-PSA/t-PSA和c-PSA/t-PSA的差異進行分析比較.結果 PCa和BPH患者中,血清t-PSA處于4～20 μw,/L區間者分彆達到68.2%和32.9%.血清t-PSA、f-PSA和c-PSA以及f-PSA/t-PSA和c-PSA/t-PSA在PCa組和BPH組之間差異均有統計學意義(P<0.05).隻有f-PSA/t-PSA和c-PSA/t-PSA在PCa和BPH組內各年齡組之間差異無統計學意義(P>0.05),結果相對穩定.血清t-PSA在4-20μg/L區間時,以f-PSA/t-PSA<0.16作為診斷PCa的指標,診斷PCa的敏感度、特異度、暘性預測值和陰性預測值分彆是89.0%、78.0%、60.7%和94.6%,以c-PSA/t-PSA>0.84作為診斷PCa的指標時,分彆是91.8%、81.3%、66.3%和96.1%.結論 PCa和BPH患者血清t-PSA在4～20μg/L區間存在較大重疊.在此區間,f-PSA/t-PSA<0.16和c-PSA/t-PSA>0.84可作為診斷PCa較為理想的標準.
목적 탐토전렬선특이성항원상관지표검측재전렬선암(PCa)여량성전렬선증생(BPH)감별진단중적작용.방법 대5가의원107례PCa환자화319례BPH환자적혈청총전렬선특이성항원(t-PSA)、유리전렬선특이성항원(f-PSA)、결합전렬선특이성항원(c-PSA)、f-PSA/t-PSA화c-PSA/t-PSA적차이진행분석비교.결과 PCa화BPH환자중,혈청t-PSA처우4～20 μw,/L구간자분별체도68.2%화32.9%.혈청t-PSA、f-PSA화c-PSA이급f-PSA/t-PSA화c-PSA/t-PSA재PCa조화BPH조지간차이균유통계학의의(P<0.05).지유f-PSA/t-PSA화c-PSA/t-PSA재PCa화BPH조내각년령조지간차이무통계학의의(P>0.05),결과상대은정.혈청t-PSA재4-20μg/L구간시,이f-PSA/t-PSA<0.16작위진단PCa적지표,진단PCa적민감도、특이도、양성예측치화음성예측치분별시89.0%、78.0%、60.7%화94.6%,이c-PSA/t-PSA>0.84작위진단PCa적지표시,분별시91.8%、81.3%、66.3%화96.1%.결론 PCa화BPH환자혈청t-PSA재4～20μg/L구간존재교대중첩.재차구간,f-PSA/t-PSA<0.16화c-PSA/t-PSA>0.84가작위진단PCa교위이상적표준.
Objective To study the value of a series of indexes derived from prostate specific antigens (PSA) in differential diagnosis of prostate cancer (PCa) and benign prostate hyperplasia (BPH). Methods The difference in serum total PSA (t-PSA), free PSA (f-PSA), combined PSA (c-PSA), fPSA/c-PSA and c-PSA/t-PSA between 107 cases of PCa and 319 cases of BPH from 5 hospitals was compared. Results The percentage of patients with serum t-PSA between 4-20 μ/L was 68.2% and 32.9% in PCa and BPH respectively. The difference in t-PSA,f-PSA, c-PSA,f-PSA/t-PSA and c-PSA/t-PSA was statistically significant between PCa and BPH (P<0.05 ). f-PSA/t-PSA and c-PSA/t-PSA had no statistically significant difference among various age groups (P>0.05), indicating that the two indexes were not fluctuant with age. When serum t-PSA was 4-20 μg/L, the sensitivity, specificity, positive predictive value, and negative predictive value of f-PSA/t-PSA <0. 16 to PCa were 89.0% ,78.0% ,60.7% and 94.6% respectively,and those of c-PSA/t-PSA >0.84 to PCa were 91.8% ,81.3% ,66.3% and 96.1% ,respectively. Conclusion The value of serum t-PSA was overlapped in the interval of 4 to 20 μg/L between PCa and PSA. f-PSA/t-PSA <0.16 and c-PSA/t-PSA >0.84 may be good standards in diagnosis of PCa.
