CAJ | 학술논문

目的评价美安颗粒治疗黄褐斑的效果和安全性,并观察其复发率.方法将确诊并符合一定入选标准的黄褐斑患者158例分为3组进行治疗:A组54例,口服美安颗粒1次1袋,1日1次；B组51例,口服美安颗粒1次1袋,1日2次；C组(对照组)53例,口服安体欣3粒,1日2次.疗程均为2个月,评价黄褐斑疗效和安全性.随访1个月,评价黄褐斑的复发率.结果 A、B、C组治疗黄褐斑的有效率分别为58％、52％、60％,3组有效率差异无统计学意义(P＞0.05).停药1个月后,3组的复发率分别为3.3％、15.3％、10.0％.3组的不良反应发生率分别为14.8％、15.6％、7.5％.结论美安颗粒治疗黄褐斑疗效明显,临床用药安全.
목적 평개미안과립치료황갈반적효과화안전성,병관찰기복발솔.방법 장학진병부합일정입선표준적황갈반환자158례분위3조진행치료:A조54례,구복미안과립1차1대,1일1차；B조51례,구복미안과립1차1대,1일2차；C조(대조조)53례,구복안체흔3립,1일2차.료정균위2개월,평개황갈반료효화안전성.수방1개월,평개황갈반적복발솔.결과 A、B、C조치료황갈반적유효솔분별위58％、52％、60％,3조유효솔차이무통계학의의(P＞0.05).정약1개월후,3조적복발솔분별위3.3％、15.3％、10.0％.3조적불량반응발생솔분별위14.8％、15.6％、7.5％.결론 미안과립치료황갈반료효명현,림상용약안전.
Objective To evaluate the efficacy and safety of Meian granule in the treatment of patients with melasma and to investigate the recurrence rate.Methods The patients,who were diag nosed pathologically as melasma from November 2010 to April 2011 in our department and accorded with the standards that we supposed,were enrolled in this study.They were then divided into three groups:Meian granule group (group A),Meian granule group (group B) and control group (group C).Patients in group A were given a packet of Meian granule each time,once a day,and those in group B were given a packet of Meian granule each time,twice a day for 2 months.Patients in group C were treated by Antixin (3 pills,thrice a day).The efficacy and safety were observed and analyzed by using statistical methods after the treatment.All the cases were followed up for a month at out-patient department or by telephone.Results A total of 158 cases of melasma were treated,including 54 cases in group A,51 cases in group B,and 53 cases in group C. The effective rates were 58 ％,52 ％,and 60 ％ in groups A,B and C,respectively.There was no significantly statistical difference (P＞0.05) of effective rates amoung the three groups.One month after the treatment the recurrence rates were 3.3 ％,15.3 ％,and 10.0 ％ in the groups A,B and C,respectively.The incidence of adverse reactions during the study were 14.8 ％,15.6 ％,and 7.5 ％,respectively.Conclusions It has been proved that Meian granule is an effective and reliable treatment for melasma.