CAJ | 학술논문

恶性肿瘤能够有效的逃避免疫系统的监视源于免疫反应系统功能的障碍,多种因素都可导致抗肿瘤免疫的失效.调节性T细胞(Tr)在肿瘤浸润的淋巴细胞及肿瘤引流的淋巴结中高频出现,意味着其能促进肿瘤生长.Tr在肿瘤免疫病理以及调节免疫治疗的效果中起重要作用.因此,肿瘤患者的Tr可能成为重要的治疗靶细胞,并将会为抗肿瘤免疫治疗提供新策略.
악성종류능구유효적도피면역계통적감시원우면역반응계통공능적장애,다충인소도가도치항종류면역적실효.조절성T세포(Tr)재종류침윤적림파세포급종류인류적림파결중고빈출현,의미착기능촉진종류생장.Tr재종류면역병리이급조절면역치료적효과중기중요작용.인차,종류환자적Tr가능성위중요적치료파세포,병장회위항종류면역치료제공신책략.
Malignant tumors could evade the immune system by impaired the function of immune responses.Multiple factors are involved in the failure of anti-tumor immune responses.Regulatory T cells(Tregs)play a crucial rote in tumor immune pathogenesis and temper immune therapeutic efficacy.Tregs are present in high frequencies among tumor-infiltrating lymphocytes and in draining lymph nodes,facilitating tumor development.Therefore,Treg cells may serve as an important therapeutic target for patients with malignant tumors and new strategies in immunotherapy against tumors.