国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
5期
371-374
,共4页
YKL-40%BRP-39%哮喘%气道炎症
YKL-40%BRP-39%哮喘%氣道炎癥
YKL-40%BRP-39%효천%기도염증
YKL-40%BRP-39%Asthma%Inflammation
支气管哮喘(简称哮喘)是一种由多种炎症细胞、炎症因子参与的慢性气道炎症性疾病,Th2分化过度在哮喘气道炎症中起重要作用.YKL-40(BRP-39)是新近发现的壳质酶类似物蛋白,参与多种疾病的炎症反应、组织结构重塑等病理过程.YKL-40可通过促进哮喘患者Th2活化、分化并减少其凋亡,增加Th2数量,在哮喘慢性气道炎症中起着重要作用.
支氣管哮喘(簡稱哮喘)是一種由多種炎癥細胞、炎癥因子參與的慢性氣道炎癥性疾病,Th2分化過度在哮喘氣道炎癥中起重要作用.YKL-40(BRP-39)是新近髮現的殼質酶類似物蛋白,參與多種疾病的炎癥反應、組織結構重塑等病理過程.YKL-40可通過促進哮喘患者Th2活化、分化併減少其凋亡,增加Th2數量,在哮喘慢性氣道炎癥中起著重要作用.
지기관효천(간칭효천)시일충유다충염증세포、염증인자삼여적만성기도염증성질병,Th2분화과도재효천기도염증중기중요작용.YKL-40(BRP-39)시신근발현적각질매유사물단백,삼여다충질병적염증반응、조직결구중소등병리과정.YKL-40가통과촉진효천환자Th2활화、분화병감소기조망,증가Th2수량,재효천만성기도염증중기착중요작용.
Bronchial asthma (athsma) is a chronic airway inflammatory disease involving a variety of inflammatory cells and mediators,excessive Th2 polarization play key role in asthmatic airway inflammation. YKL-40 (BRP-39) is a newly discovered chitinase-like protein and participates in inflammatory reaction,tissue remodeling in various diseases. YKL-40 can increase Th2 number by promoting their activation and differentiation as well as reducing their apoptosis in asthma patients,and play an important role in chronic airway inflammation of asthma.
