CAJ | 학술논문

目的探讨术前动脉化疗栓塞对膀胱癌组织中核增殖相关抗原(gi-67)表达的影响.方法对30例动脉化疗栓塞前后的膀胱癌组织,应用免疫组化方法测定Ki-67的表达,并分析Ki-67与膀胱癌病理分级和临床分期的关系.结果动脉化疗栓塞前后Ki-67阳性和强阳性表达率分别为70.00%、26.67%,差异有统计学意义(P＜0.01).30例患者平均随访24.6个月,复发率为16.67%.Ki-67阳性表达及动脉化疗栓塞前后降低幅度与膀胱癌的病理分级、临床分期和患者术后复发率关系密切.结论 Ki-67的表达可作为膀胱癌预后评估的指标.
목적 탐토술전동맥화료전새대방광암조직중핵증식상관항원(gi-67)표체적영향.방법 대30례동맥화료전새전후적방광암조직,응용면역조화방법측정Ki-67적표체,병분석Ki-67여방광암병리분급화림상분기적관계.결과 동맥화료전새전후Ki-67양성화강양성표체솔분별위70.00%、26.67%,차이유통계학의의(P＜0.01).30례환자평균수방24.6개월,복발솔위16.67%.Ki-67양성표체급동맥화료전새전후강저폭도여방광암적병리분급、림상분기화환자술후복발솔관계밀절.결론 Ki-67적표체가작위방광암예후평고적지표.
Objective To investigate the influence of preoperative arterial chemoembolization on expression of Ki-67,and clinical significance in bladder cancer. Methods Before and after chemoembolizafion of therapy,the expression of Ki-67 in 30 patients of bladder cancer tissue were examined by immunohistochemical staining.The rehtion of its expression to the pathological grade and clinical stage was evaluated clinically.Results Positive rate of Ki-67 expression in the bladder cancer tissue was 70.00% and 26.67% respectively.There was significant difference between the before and after therapy (P＜0.01). Follow-up for mean 24.6 months recurrence rate in 30 cases was 16.67%.The expression of Ki-67 correhted to the pathological grade, clinical stage and patient recurrence rates of bladder cancer.Conclusions Preoperative arterial chemeembelization can reduce the expression of Ki-67,adjust malignancy of bladder cancer,could downgrade and downstage the tumors,and cut down the postoperative metastasis,improve survival rate and reduce recurrence rate.Both of the Ki-67 labeling index are predictive factor for recurrence of superficial bladder cancer.