国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
10期
897-899
,共3页
羟基红花黄色素A%降血脂%抗氧化
羥基紅花黃色素A%降血脂%抗氧化
간기홍화황색소A%강혈지%항양화
Hydroxyl safflower yellow A%Regulating blood lipids%Anti-oxidation
目的 观察羟基红花黄色素A调节血脂的作用,并探讨其初步机理.方法 将50只小鼠按体重随机分成正常动物组(A组)、高脂血症模型组(B组)、羟基红花黄色素A注射液低、中、高三种剂量组(C、D、E组).C、D、E组每天分别注射10、40、70 mg/kg羟基红花黄色素；A、B组每天分别注射生理盐水0.4 ml.连续注射3d后,对B～E组分别造模,18h后测定所有组别胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、丙二醛(MDA)的含量及超氧化物歧化酶( SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性.结果 成模高脂血症小鼠静脉注射羟基红花黄色素高剂量组,与给药前比较,血清中TC (4.09±0.2) mmol/L、TG (0.96±0.15) mmol/L、LDL-C(5.87±0.17)mmol/L、HDL-C (0.83±0.21) mmol/L、MDA( 8.26±1.05) nmol/ml水平和SOD活性(330.18±11.45) U/ml、GSH-Px活性(1023.54±25.34) U/ml均有明显变化,差异均有统计学意义(P均＜0.05).结论 羟基红花黄色素A具有调节血脂的作用,且可能是通过抗氧化作用调节血脂.
目的 觀察羥基紅花黃色素A調節血脂的作用,併探討其初步機理.方法 將50隻小鼠按體重隨機分成正常動物組(A組)、高脂血癥模型組(B組)、羥基紅花黃色素A註射液低、中、高三種劑量組(C、D、E組).C、D、E組每天分彆註射10、40、70 mg/kg羥基紅花黃色素；A、B組每天分彆註射生理鹽水0.4 ml.連續註射3d後,對B～E組分彆造模,18h後測定所有組彆膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、丙二醛(MDA)的含量及超氧化物歧化酶( SOD)、穀胱甘肽過氧化物酶(GSH-Px)的活性.結果 成模高脂血癥小鼠靜脈註射羥基紅花黃色素高劑量組,與給藥前比較,血清中TC (4.09±0.2) mmol/L、TG (0.96±0.15) mmol/L、LDL-C(5.87±0.17)mmol/L、HDL-C (0.83±0.21) mmol/L、MDA( 8.26±1.05) nmol/ml水平和SOD活性(330.18±11.45) U/ml、GSH-Px活性(1023.54±25.34) U/ml均有明顯變化,差異均有統計學意義(P均＜0.05).結論 羥基紅花黃色素A具有調節血脂的作用,且可能是通過抗氧化作用調節血脂.
목적 관찰간기홍화황색소A조절혈지적작용,병탐토기초보궤리.방법 장50지소서안체중수궤분성정상동물조(A조)、고지혈증모형조(B조)、간기홍화황색소A주사액저、중、고삼충제량조(C、D、E조).C、D、E조매천분별주사10、40、70 mg/kg간기홍화황색소；A、B조매천분별주사생리염수0.4 ml.련속주사3d후,대B～E조분별조모,18h후측정소유조별담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)、고밀도지단백(HDL-C)、병이철(MDA)적함량급초양화물기화매( SOD)、곡광감태과양화물매(GSH-Px)적활성.결과 성모고지혈증소서정맥주사간기홍화황색소고제량조,여급약전비교,혈청중TC (4.09±0.2) mmol/L、TG (0.96±0.15) mmol/L、LDL-C(5.87±0.17)mmol/L、HDL-C (0.83±0.21) mmol/L、MDA( 8.26±1.05) nmol/ml수평화SOD활성(330.18±11.45) U/ml、GSH-Px활성(1023.54±25.34) U/ml균유명현변화,차이균유통계학의의(P균＜0.05).결론 간기홍화황색소A구유조절혈지적작용,차가능시통과항양화작용조절혈지.
Objective To investigate the effect of hydroxyl safflor yellow A on mediating blood lipid and to explore its primary mechanism.Methods Fifty KM mice were divided into five groups randomly:control group(A),hyperlipidemia model group(B),high-dose group(C),mid-dose group (D) and low-dose group(E).C,D and E group were injected by hydroxy safflor yellow A with 10,40 and 70 mg.kg-1 day-1respectively,while A and B group were both injected by saline with 0.4 ml day-1,the administrations were kept on three days.The levels of serum total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) and malondialdehyde (MDA) were assayed,simultaneously the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were assayed after 18 hours.Results Compared with the control group,the serum TC (4.09+0.2) mmol/L,TG (0.96±0.15) mmol/L,LDL-C (5.87±0.17) mmol/L,HDL-C (0.83±0.21) mmol/L,MDA (8.26+1.05) nmol/ml,and the activities of SOD (330.18 ± 11.45 ) U/ml,GSH-Px (1023.54±25.34) U/ml of model group injected high doses of hydroxysafflor yellow A were statistically significant.Conclusion Hydroxy safflor yellow A had the function of mediating blood lipid.Anti-oxidation could be the mechanism.
