CAJ | 학술논문

研究显示,烟酰胺腺嘌呤二核苷酸不但是细胞氧化还原的辅酶,而且是单腺苷酸二磷酸核糖转移酶、多聚单腺苷酸二磷酸核糖聚合酶和去乙酰化酶的底物,在多种细胞生理学功能中超重要作用.烟酰胺是合成烟酰胺腺嘌呤二核苷酸的前体,又是烟酰胺腺嘌呤二核苷酸一消耗酶的抑制剂,其作用已超出于防治糙皮病.在皮肤科,烟酰胺已用于治疗免疫性大疱病、特应性皮炎、痤疮和酒渣鼻等,并在抗皮肤老化和皮肤美容方面有良好的应用前景.烟酰胺外用的安全性已经确认,但大剂量内服尚未经规范的新药安全性评估.
연구현시,연선알선표령이핵감산불단시세포양화환원적보매,이차시단선감산이린산핵당전이매、다취단선감산이린산핵당취합매화거을선화매적저물,재다충세포생이학공능중초중요작용.연선알시합성연선알선표령이핵감산적전체,우시연선알선표령이핵감산일소모매적억제제,기작용이초출우방치조피병.재피부과,연선알이용우치료면역성대포병、특응성피염、좌창화주사비등,병재항피부노화화피부미용방면유량호적응용전경.연선알외용적안전성이경학인,단대제량내복상미경규범적신약안전성평고.
Recent studies have shown that nicotinamide adenine dinucleotide(NAD)is not only a co-enzyme in cellular oxidation.reduction reactions.but also a substrate for reactions catalyzed by mono (ADP-ribose) transferases,poly (ADP-ribose) polymemses and acetylase,and it play important roles in numerous cellular physiologic functions.Nicotinamide is not only a precursor for the synthesis of NAD,but also an inhibitor of NAD-consuming enzymes.Besides pellagra,nicotinamide has been used to ireat immune bullous diseases,atopic dermatitis,rosacea and aene,and so on.Moreover,nicotinamide has shown a favorable perspective in anti-skin aging and cosmetic dermatology.The safety of topical nicotinamide has been already confirmed.but a forlnal safety evaluation routinely designed for a new drug has not been performed for oral nicotinamide at high dose.