CAJ | 학술논문

目的探讨直肠癌彩色血流平均密度(MCVD)与微血管密度(MVD)的相关性及其与直肠癌浸润深度及淋巴转移的关系.方法术前应用经直肠彩色血管能量成像计测MCVD,术后取组织标本以抗CD105单克隆抗体行免疫组织化学染色,计数MVD,分析MCVD与MVD的相关性及其与癌肿浸润深度及淋巴结转移的关系.结果 MCVD与MVD呈正相关(r=0.763,P＜0.01).MCVD、MVD在肿瘤浸润深度及有无淋巴结转移上差异均有统计学意义(P＜0.05).结论 MCVD能反映直肠癌的血供特点及病珲微血管分布,可间接反映直肠癌的病程进展,为术前选择有效治疗方案、评估预后提供参考信息.
목적 탐토직장암채색혈류평균밀도(MCVD)여미혈관밀도(MVD)적상관성급기여직장암침윤심도급림파전이적관계.방법 술전응용경직장채색혈관능량성상계측MCVD,술후취조직표본이항CD105단극륭항체행면역조직화학염색,계수MVD,분석MCVD여MVD적상관성급기여암종침윤심도급림파결전이적관계.결과 MCVD여MVD정정상관(r=0.763,P＜0.01).MCVD、MVD재종류침윤심도급유무림파결전이상차이균유통계학의의(P＜0.05).결론 MCVD능반영직장암적혈공특점급병혼미혈관분포,가간접반영직장암적병정진전,위술전선택유효치료방안、평고예후제공삼고신식.
Objective To explore the relationship of the mean color vessels density (MCVD) and pathologic microvessel density(MVD) in rectal cancers and their relation with T stags and lymph node metastasis.Methods MCVD were caculated preoperationly with transrectal color power angiography(TRCPA).After operation MVD was assessed immunohistochemically using anti-CD105 monoclonal antibody.The relationships within MCVD, MVD and T stages and lymph node metastasis were analysed.Results There were positive correlation between MCVD and MVD (r=0.763, P＜0.01) in rectal cancer.There were significant difference of MCVD and MVD in both the depth of carcinoma invasion and metastasis of lymphatic nodes( P＜0.05).Conclusions MCVD can display features of the blood supply and distribution of pathologic microvessels and reflect the development of rectal cancers.MCVD is a credible index to choose available treatment and to evaluate prognosis before operation of rectal cancer.