CAJ | 학술논문

目的探讨不同运动训练时程对大鼠脊髓损伤后运动、神经功能恢复的影响.方法 Sprague-Dawley大鼠95只,分为模型组(未给予运动训练)、实验组(根据训练时程分为训练1周、2周、3周、4周组)和假手术组(切除椎板暴露脊髓,但不造成脊髓损伤).采用改良Allen撞击法制作胸髓(T_(10))不完全损伤模型.运动方式采用重量支撑平板步行训练,在不同时间点采用斜板试验、改良Tarlov评分、Basso-Beattie-Bresnahan(BBB)评分、脊髓体感诱发电位进行运动及神经功能评定.结果 ①运动功能:大鼠运动训练1,2,3和4周后,运动功能均较模型组有明显提高(P<0.05);②脊髓体感诱发电位:大鼠运动训练2,3和4周后,N1波峰潜伏期较模型组显著缩短(P<0.05),且随训练时程增加而逐步缩短(P<0.05).结论部分重量支撑平板步行训练能有效改善不完全性脊髓损伤大鼠运动及神经功能,并且其改善作用与运动训练时程相关.
목적 탐토불동운동훈련시정대대서척수손상후운동、신경공능회복적영향.방법 Sprague-Dawley대서95지,분위모형조(미급여운동훈련)、실험조(근거훈련시정분위훈련1주、2주、3주、4주조)화가수술조(절제추판폭로척수,단불조성척수손상).채용개량Allen당격법제작흉수(T_(10))불완전손상모형.운동방식채용중량지탱평판보행훈련,재불동시간점채용사판시험、개량Tarlov평분、Basso-Beattie-Bresnahan(BBB)평분、척수체감유발전위진행운동급신경공능평정.결과 ①운동공능:대서운동훈련1,2,3화4주후,운동공능균교모형조유명현제고(P<0.05);②척수체감유발전위:대서운동훈련2,3화4주후,N1파봉잠복기교모형조현저축단(P<0.05),차수훈련시정증가이축보축단(P<0.05).결론 부분중량지탱평판보행훈련능유효개선불완전성척수손상대서운동급신경공능,병차기개선작용여운동훈련시정상관.
Objective To investigate the effect of exercise on the recovery of locomotor and neurological function in rats after incomplete spinal cord injury (SCI). Methods Ninety-five male Sprague Dawley rats were randomly divided into a control group, a training group (including subgroups which received training for 1 week, 2 weeks, 3 weeks and 4 weeks) and a sham operation group. The control and training groups were administered an SCI model at the T_(10) level by extradural compression using a modified Allen's stall with a damage energy of 40 g-cm. These rats were loosely restrained and given partial weight-bearing treadmill training 5min/time, twice a day for 1-4 weeks. Locomotor and neurological function were evaluated with inclined plane tests, modified Tarlov scores, the Basso-Beattie-Bresnahan scale and spinal cord somatosensory evoked potential (SCSEP) before injury and at different time points thereafter. Results Locomotor function improved significantly at different time points during the train-ing, and significantly better than in the control group. In the rats trained for 2-4 weeks, SCSEP latency shortened sig-nificantly compared to the control group. The latency shortened gradually with longer exercise. Conclusions Exer-cise with partial weight support may improve locomotor and neurological function. The improvements are correlated closely with the duration of the training.