CAJ | 학술논문

目的结合视神经脊髓炎(NMO)与多发性硬化(MS)患者的临床症状和脊髓MRI特点探讨两者之间差异发生的机制.方法回顾性分析中山大学附属第三医院自2004年1月至2007年1月收治的23例NMO患者及21例MS患者的临床资料,比较其临床症状及脊髓MRI上受损部位MRI上的差异.结果 NMO患者多为女性,且首次发病年龄、扩展病残状况评分(EDSS)评分均高于MS患者;双侧深感觉障碍、束带感、直肠或膀胱括约肌功能障碍3种临床症状在NMO、MS患者中的发生率不同,差异均有统计学意义(P<0.05);上述各临床症状基本能在脊髓MRI找到相应受损病灶.结论 NMO是不同于MS的脱髓鞘疾病,其特殊的发病机制导致其临床症状与脊髓MRI均有自己的特点.
목적 결합시신경척수염(NMO)여다발성경화(MS)환자적림상증상화척수MRI특점탐토량자지간차이발생적궤제.방법 회고성분석중산대학부속제삼의원자2004년1월지2007년1월수치적23례NMO환자급21례MS환자적림상자료,비교기림상증상급척수MRI상수손부위MRI상적차이.결과 NMO환자다위녀성,차수차발병년령、확전병잔상황평분(EDSS)평분균고우MS환자;쌍측심감각장애、속대감、직장혹방광괄약기공능장애3충림상증상재NMO、MS환자중적발생솔불동,차이균유통계학의의(P<0.05);상술각림상증상기본능재척수MRI조도상응수손병조.결론 NMO시불동우MS적탈수초질병,기특수적발병궤제도치기림상증상여척수MRI균유자기적특점.
Objective To investigate the differences in the clinical symptoms and magnetic resonance imaging (MPd) findings of the spinal cord lesions between patients with neuromyelitis optica (NMO) and multiple sclerosis (MS) and explore the mechanisms that result in these differences. Methods The clinical symptoms and MRI findings of the spinal cord were retrospectively analyzed in 21 MS patients and 23 NMO patients admitted in the Third Affiliated Hospital of Sun Yat-Sen University from January, 2004 to January, 2007. Results Female patients were more frequently affected by NMO, and the NMO patients had a older mean age at onset with higher Expanded Disability Status Scale (EDSS) score than the MS patients. Chi-square test showed significant differences in the rotes of bilateral deep sensory dysfunction, zonesthesia, and sphincter disturbance between the NMO and MS patients (P<0.05). The majority of these clinical symptoms were found to result form corresponding spinal cord lesions defined by MRI. Conclusion NMO is a demyelinating disease that represents an independent clinical entity from MS, and has special mechanisms responsible for its characteristic clinical symptoms and MRI findings of the spinal cord.