中华围产医学杂志
中華圍產醫學雜誌
중화위산의학잡지
CHINESE JOURNAL OF PERINATAL MEDICINE
2008年
6期
377-381
,共5页
陈海天%王子莲%詹雁峰%彭扬水%李铭岚
陳海天%王子蓮%詹雁峰%彭颺水%李銘嵐
진해천%왕자련%첨안봉%팽양수%리명람
糖尿病%妊娠%脂类%婴儿%新生%人体质量指数
糖尿病%妊娠%脂類%嬰兒%新生%人體質量指數
당뇨병%임신%지류%영인%신생%인체질량지수
Diabetes,gestational%Lipids%Infant,newborn%Macrosomia
目的 探讨在血糖控制良好的糖代谢异常的孕妇中,脐血血脂与新生儿体质指数的关系. 方法 收集2006年11月至2007年2月住院分娩的孕妇150例,其中糖代谢异常(包括妊娠期糖尿病和妊娠期糖代谢异常)且血糖控制良好的孕妇73例,糖耐量正常的孕妇77例,其新生儿分为大于胎龄儿(large for gestational age,LGA)25例和适于胎龄儿(appropriate forgestational age,AGA)125例两组.分析两组新生儿的体质指数、脐血血脂[包括高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low density lipoprotein,LDL)、甘油三酯(triglyceride,TG)、总胆固醇(total cholestrol,TC)]等指标,并对上述指标进行比较和相关、回归分析. 结果 脐血HDL、LDL、TC水平在两组间无差异,脐血TG水平LGA组高于AGA组[(0.23±0.16)mmol/L和(0.14±0.08)mmol/L,P＜0.05].在糖代谢异常孕妇的新生儿中,LGA儿的出生体重与脐血TG水平正相关(r=0.625,P＜0.05),与脐血HDL、LDL、TC不相关.在糖耐量正常孕妇的新生儿中,LGA儿的体质指数与脐血血脂指标均不相关.分娩LGA儿的危险因素为:孕期增重≥18 kg,脐血TG＞0.11 mmol/L. 结论 血脂代谢与新生儿体质指数密切相关;脐血TG可能参与了精代谢异常孕妇分娩LGA的发病机制;脐血TG＞0.11 mmol/L时更容易发生LGA.
目的 探討在血糖控製良好的糖代謝異常的孕婦中,臍血血脂與新生兒體質指數的關繫. 方法 收集2006年11月至2007年2月住院分娩的孕婦150例,其中糖代謝異常(包括妊娠期糖尿病和妊娠期糖代謝異常)且血糖控製良好的孕婦73例,糖耐量正常的孕婦77例,其新生兒分為大于胎齡兒(large for gestational age,LGA)25例和適于胎齡兒(appropriate forgestational age,AGA)125例兩組.分析兩組新生兒的體質指數、臍血血脂[包括高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low density lipoprotein,LDL)、甘油三酯(triglyceride,TG)、總膽固醇(total cholestrol,TC)]等指標,併對上述指標進行比較和相關、迴歸分析. 結果 臍血HDL、LDL、TC水平在兩組間無差異,臍血TG水平LGA組高于AGA組[(0.23±0.16)mmol/L和(0.14±0.08)mmol/L,P＜0.05].在糖代謝異常孕婦的新生兒中,LGA兒的齣生體重與臍血TG水平正相關(r=0.625,P＜0.05),與臍血HDL、LDL、TC不相關.在糖耐量正常孕婦的新生兒中,LGA兒的體質指數與臍血血脂指標均不相關.分娩LGA兒的危險因素為:孕期增重≥18 kg,臍血TG＞0.11 mmol/L. 結論 血脂代謝與新生兒體質指數密切相關;臍血TG可能參與瞭精代謝異常孕婦分娩LGA的髮病機製;臍血TG＞0.11 mmol/L時更容易髮生LGA.
목적 탐토재혈당공제량호적당대사이상적잉부중,제혈혈지여신생인체질지수적관계. 방법 수집2006년11월지2007년2월주원분면적잉부150례,기중당대사이상(포괄임신기당뇨병화임신기당대사이상)차혈당공제량호적잉부73례,당내량정상적잉부77례,기신생인분위대우태령인(large for gestational age,LGA)25례화괄우태령인(appropriate forgestational age,AGA)125례량조.분석량조신생인적체질지수、제혈혈지[포괄고밀도지단백(high density lipoprotein,HDL)、저밀도지단백(low density lipoprotein,LDL)、감유삼지(triglyceride,TG)、총담고순(total cholestrol,TC)]등지표,병대상술지표진행비교화상관、회귀분석. 결과 제혈HDL、LDL、TC수평재량조간무차이,제혈TG수평LGA조고우AGA조[(0.23±0.16)mmol/L화(0.14±0.08)mmol/L,P＜0.05].재당대사이상잉부적신생인중,LGA인적출생체중여제혈TG수평정상관(r=0.625,P＜0.05),여제혈HDL、LDL、TC불상관.재당내량정상잉부적신생인중,LGA인적체질지수여제혈혈지지표균불상관.분면LGA인적위험인소위:잉기증중≥18 kg,제혈TG＞0.11 mmol/L. 결론 혈지대사여신생인체질지수밀절상관;제혈TG가능삼여료정대사이상잉부분면LGA적발병궤제;제혈TG＞0.11 mmol/L시경용역발생LGA.
Objective To explore the relationship of lipid metabolism with neonatal body index in mothers with abnormal glucose metabolism during pregnancy and how lipid metabolism inflenees fetal growth. Methods This study recruited 150 mothers and their babies admitted in our hospital from November 2006 to February 2007 including 73 eases of abnormal glucose metabolism with good glycemic control and 77 with normal glucose tolerance. The babies were divided into two groups:LGA (n=25) and AGA (n=125). Clinical data and serum lipid profiles(HDL,LDL,TG,TC)in cord blood were obtained and analyzed Results No significant difference in cord blood levels of HDL, LDL, TC were found between LGA and AGA group, however, with mild elevated TG level in LGA group [(0. 23±0. 16) mmol/L vs (0. 14±0.08)mmol/L,P<0. 05]. In newborns of mothers with abnormal glucose metabolism, the birth weight of LGA infanta was positively correlated with cord blood TG level(r= 0. 625, P<0. 05), but not with the HDL, LDL or TC level. In newborns of mothers with normal glucose tolerance, the body index of LGA infants was not correlated with cord blood lipid profiles. Risk factors of delivering LGA infants were:weight gain during pregnancy≥18 kg, cord blood TG>0. 11 mmol/L. Conclusions LGA infants have a higher level of cord blood TG than AGA which implies that cord blood TG may play a role in fetal overgrowth in mothers with abnormal glucose metabolism. LGAs are more likely to occur when cord blood TG＞0. 11 mmol/L.
