CAJ | 학술논문

目的比较阿托伐他汀与多西环素对心绞痛病人临床疗效及对运动耐量的影响.方法选择60例冠心病稳定型心绞痛伴血脂正常病人,随机分为2组,分别予阿托伐他汀10mg,po,qn×8wk及多西环素100mg,po,qd×8wk,比较每周心绞痛发作次数及硝酸甘油消耗量,运动耐量及血脂水平.结果阿托伐他汀及多西环素均能减少心绞痛发作次数、硝酸甘油消耗量,运动至出现ST段压低1mm所需时间、心绞痛所需时间、ST段缺血型下移之和明显减少,运动持续时间显著延长.结论阿托伐他汀及多西环素均缓解稳定型心绞痛病人症状,改善运动诱发的心肌缺血,提高运动耐量,疗效相类似.
목적 비교아탁벌타정여다서배소대심교통병인림상료효급대운동내량적영향.방법 선택60례관심병은정형심교통반혈지정상병인,수궤분위2조,분별여아탁벌타정10mg,po,qn×8wk급다서배소100mg,po,qd×8wk,비교매주심교통발작차수급초산감유소모량,운동내량급혈지수평.결과 아탁벌타정급다서배소균능감소심교통발작차수、초산감유소모량,운동지출현ST단압저1mm소수시간、심교통소수시간、ST단결혈형하이지화명현감소,운동지속시간현저연장.결론 아탁벌타정급다서배소균완해은정형심교통병인증상,개선운동유발적심기결혈,제고운동내량,료효상유사.
Objective To evaluate the efficacy of atorvastatin and doxycycline on exercise tolerance in patients with stable angina pectoris. Methods Sixty patients with normal lipoidemia provened coronary artery disease by angiographical were given atorvastatin or doxycycline for 8 wk randomly. Treadmill exercise testing was adopted to invesgate exercise tolerance before and after therapy. Results After atorvastatin or doxycycline treating, angina petoris attack frequency and consumption of nitroglycerin weekly were decreased obviously; the time for inducing angina and 0.1 mv ST segment depression, the total exercise time and ΣST depression by exercise were improved obviously in both groups. The serum total cholesterol, triglyceride were decreased and HDL-Cholesterol level increased only in atorvastatin group. Conclusion Both atorvastatin and doxycycline have obvious anti-ischemic efficacy in patients with stable angina pectoris, improve myocardial ischemia and exercise tolerance induced by exercise. Atorvastatin improves lipid profile also.