中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2010年
6期
374-377
,共4页
朱燕娟%陈晓泓%张博恒%邱双健%樊嘉%任正刚%夏景林%王艳红%干育红%叶胜龙
硃燕娟%陳曉泓%張博恆%邱雙健%樊嘉%任正剛%夏景林%王豔紅%榦育紅%葉勝龍
주연연%진효홍%장박항%구쌍건%번가%임정강%하경림%왕염홍%간육홍%협성룡
肝细胞癌%分期系统%判断预后%指导治疗
肝細胞癌%分期繫統%判斷預後%指導治療
간세포암%분기계통%판단예후%지도치료
Hepatocellular carcinoma%Staging systems%Prognostic ability%Therapeutic guiding ability
目的 比较4个分期系统[巴塞罗那临床肝癌分期标准(BCLC)、日本综合分期积分(JIS)、意大利肝癌评分(CLIP)和国内分期]对中国肝癌患者预后判断和对治疗方案选择的指导意义.方法 回顾性分析2001年至2002年复旦大学附属中山医院收治的861例初发肝细胞癌患者的临床资料,分别按4个分期系统分期或评分,比较各期患者的生存情况以及不同治疗方案对其生存的影响.结果 在判断预后方面,BCLC、JIS和国内分期系统的各分期间生存率差异均有统计学意义;而在CLIP分期的一些评分间的生存率差异无统计学意义.在指导治疗方面,BCLC C期,CLIP 3、4分以及国内分期ⅢA期的患者接受手术治疗与接受肝动脉化学治疗栓塞(TACE)和(或)肝动脉栓塞(TAE)治疗的生存率差异无统计学意义;而比这些更早期的患者接受手术治疗的生存率优于接受TACE和(或)TAE治疗的生存率.结论 BCLC、JIS和国内分期系统在判断预后方面适用于中国患者;但仅国内分期和BCLC分期同时兼备了判断预后和指导治疗两方面的作用.
目的 比較4箇分期繫統[巴塞囉那臨床肝癌分期標準(BCLC)、日本綜閤分期積分(JIS)、意大利肝癌評分(CLIP)和國內分期]對中國肝癌患者預後判斷和對治療方案選擇的指導意義.方法 迴顧性分析2001年至2002年複旦大學附屬中山醫院收治的861例初髮肝細胞癌患者的臨床資料,分彆按4箇分期繫統分期或評分,比較各期患者的生存情況以及不同治療方案對其生存的影響.結果 在判斷預後方麵,BCLC、JIS和國內分期繫統的各分期間生存率差異均有統計學意義;而在CLIP分期的一些評分間的生存率差異無統計學意義.在指導治療方麵,BCLC C期,CLIP 3、4分以及國內分期ⅢA期的患者接受手術治療與接受肝動脈化學治療栓塞(TACE)和(或)肝動脈栓塞(TAE)治療的生存率差異無統計學意義;而比這些更早期的患者接受手術治療的生存率優于接受TACE和(或)TAE治療的生存率.結論 BCLC、JIS和國內分期繫統在判斷預後方麵適用于中國患者;但僅國內分期和BCLC分期同時兼備瞭判斷預後和指導治療兩方麵的作用.
목적 비교4개분기계통[파새라나림상간암분기표준(BCLC)、일본종합분기적분(JIS)、의대리간암평분(CLIP)화국내분기]대중국간암환자예후판단화대치료방안선택적지도의의.방법 회고성분석2001년지2002년복단대학부속중산의원수치적861례초발간세포암환자적림상자료,분별안4개분기계통분기혹평분,비교각기환자적생존정황이급불동치료방안대기생존적영향.결과 재판단예후방면,BCLC、JIS화국내분기계통적각분기간생존솔차이균유통계학의의;이재CLIP분기적일사평분간적생존솔차이무통계학의의.재지도치료방면,BCLC C기,CLIP 3、4분이급국내분기ⅢA기적환자접수수술치료여접수간동맥화학치료전새(TACE)화(혹)간동맥전새(TAE)치료적생존솔차이무통계학의의;이비저사경조기적환자접수수술치료적생존솔우우접수TACE화(혹)TAE치료적생존솔.결론 BCLC、JIS화국내분기계통재판단예후방면괄용우중국환자;단부국내분기화BCLC분기동시겸비료판단예후화지도치료량방면적작용.
Objective To compare the Barcelona clinic liver cancer staging classification (BCLC), the Japan integrated staging score (JIS), the cancer of the liver Italian program score (CLIP) and Chinese staging system in terms of their ability to predict outcomes and to guide option of therapy in patients with hepatocellular carcinoma (HCC) in China.Methods Clinical data of 861 HCC patients from Zhongshan Hospital between 2001 and 2002 were retrospectively analyzed. Patients were classified acccording to different staging systems. Survival for patients in different stages and the effects of therapeutic methods on survival time were compared. Results BCLC, JIS and Chinese staging system showed the ability in predicting survival for patients in different staging. CLIP failed to show significant difference in survival rates for each subgroup. There was no significant difference in survival rate between surgery and transarterial chemoembolization (TACE)/transarterial embolization (TAE) for patients classified as BCLC stage C, CLIP scores more than 3 or Chinese stage Ⅲ a.The survival rate, however, was higher in patients received operation than those received TACE/TAE if they were classified as earlier stages. Conclusions The BCLC, JIS and Chinese staging systems show prospective ability for Chinese HCC patients in prediction outcomes, whereas the BCLC and the Chinese staging systems are better at both predicting outcomes and guiding the option of treatment.
