中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2008年
2期
108-109
,共2页
蔡俊明%李涛%张允奇%张国良%李松%许香广
蔡俊明%李濤%張允奇%張國良%李鬆%許香廣
채준명%리도%장윤기%장국량%리송%허향엄
血小板膜糖蛋白类%冠状动脉硬化%流式细胞术
血小闆膜糖蛋白類%冠狀動脈硬化%流式細胞術
혈소판막당단백류%관상동맥경화%류식세포술
Platelet membrane glycoproteins%Coronary arteriosclerosis%Flow cytometry
目的 检测冠心病患者全血血小板α膜糖蛋白(CD62P)阳性表达与冠状动脉病变程度,探讨CD62P在冠心病中的作用.方法 采用流式细胞术(FCM)测定70例冠心病患者的外周血CD62P的阳性表达水平,其中稳定型心绞痛(SAP组)28例、不稳定型心绞痛(UAP组)26例和急性心肌梗死(AMI组)16例,20例非冠心病患者作为对照.结果 70例冠状动脉造影均为阳性,CD62P表达率在不稳定型心绞痛组为(28.3±20.1)%,急性心肌梗死组为(20.5±16.3)%,稳定型心绞痛组为(12.8±13.3)%,非冠心病对照组为(9.9±6.4)%,不稳定型心绞痛组与对照组及稳定型心绞痛组比较、冠脉1～3支病变比较差异均有统计学意义.结论 不稳定型心绞痛者体内CD62P水平明显增高,与冠脉病变的严重程度相关.
目的 檢測冠心病患者全血血小闆α膜糖蛋白(CD62P)暘性錶達與冠狀動脈病變程度,探討CD62P在冠心病中的作用.方法 採用流式細胞術(FCM)測定70例冠心病患者的外週血CD62P的暘性錶達水平,其中穩定型心絞痛(SAP組)28例、不穩定型心絞痛(UAP組)26例和急性心肌梗死(AMI組)16例,20例非冠心病患者作為對照.結果 70例冠狀動脈造影均為暘性,CD62P錶達率在不穩定型心絞痛組為(28.3±20.1)%,急性心肌梗死組為(20.5±16.3)%,穩定型心絞痛組為(12.8±13.3)%,非冠心病對照組為(9.9±6.4)%,不穩定型心絞痛組與對照組及穩定型心絞痛組比較、冠脈1～3支病變比較差異均有統計學意義.結論 不穩定型心絞痛者體內CD62P水平明顯增高,與冠脈病變的嚴重程度相關.
목적 검측관심병환자전혈혈소판α막당단백(CD62P)양성표체여관상동맥병변정도,탐토CD62P재관심병중적작용.방법 채용류식세포술(FCM)측정70례관심병환자적외주혈CD62P적양성표체수평,기중은정형심교통(SAP조)28례、불은정형심교통(UAP조)26례화급성심기경사(AMI조)16례,20례비관심병환자작위대조.결과 70례관상동맥조영균위양성,CD62P표체솔재불은정형심교통조위(28.3±20.1)%,급성심기경사조위(20.5±16.3)%,은정형심교통조위(12.8±13.3)%,비관심병대조조위(9.9±6.4)%,불은정형심교통조여대조조급은정형심교통조비교、관맥1～3지병변비교차이균유통계학의의.결론 불은정형심교통자체내CD62P수평명현증고,여관맥병변적엄중정도상관.
Objective To investigate the role of alpha-granulemembrane protein(CD62P),marker of plate activation,in the patients with coronary heart disease(CHD)and to investigate the relationship between the severity of coronary artery stenosis and platelet activation.Methods Peripheral blood samples were collected from 70 patients with CHD,including 28 cases of stable angina pectoris(SAP),26 cases of unstable angina pectoris(UAP),and 16 cases of acute myocardial infarction(AMI),all of which underwent coronary arteriography,and 20 angiographically normal persons as no-CHD controls.The CD62P level was analyzed by flow cytometry(FCM).Resuits Coronary arteriography showed positivity in 70 of the 90 CHD patients.The CD62P positive rate of the UAP group was(28.3±20.1)%,significantly higher than those of the SAP group[(12.8 ±13.3)%]and no-CHD group[(9.9 ±6.4)%,both P＜0.05].The CD62P positive rate of the double vessel disease group was(24.0 ±17.8)%,not significantly different from that of the three-vessel disease group[(22.6±20.4)%],but significantly higher than that of the single-vessel disease group[(11.1 ±8.5)%]and that of the no-CHD group[(9.9 ±6.4)%,both P＜0.05].Condusion The platelet alpha-granulemembrane protein CD62P level is higher in the UAP patients.It is related to the pathophysiological process of UAP and the severity of coronary artery stenosis.
