CAJ | 학술논문

目的了解医院鲍曼不动杆菌感染的分布及耐药情况.方法分析鲍曼不动杆菌菌株的标本来源和临床分布情况,用最低抑菌浓度(minimal inhibitory concentration,MIC)法结合纸片扩散法(K-B法)检测其对抗菌药物的敏感性.结果 2007-2010年共分离鲍曼不动杆菌62株,其中53株(占85.5%)分离自痰标本,21株(占33.9%)分离自重症监护室(intensive care units,ICU).62例患者中54.8%(34例)的患者患有严重的肺部感染疾病.分离菌对头孢哌酮/舒巴坦的耐药率为20.0%、敏感率为73.3%,对其他抗菌药物的耐药率超过60.0%.泛耐药菌占33.9%(21株),其中52.4%(11株)的泛耐药鲍曼不动杆菌感染发生在ICU病房.结论鲍曼不动杆菌的耐药率较高,且呈多重耐药趋势.加强菌株的耐药性监测,以药敏结果指导临床用药有助于减少耐药菌株的出现.
목적 료해의원포만불동간균감염적분포급내약정황.방법 분석포만불동간균균주적표본래원화림상분포정황,용최저억균농도(minimal inhibitory concentration,MIC)법결합지편확산법(K-B법)검측기대항균약물적민감성.결과 2007-2010년공분리포만불동간균62주,기중53주(점85.5%)분리자담표본,21주(점33.9%)분리자중증감호실(intensive care units,ICU).62례환자중54.8%(34례)적환자환유엄중적폐부감염질병.분리균대두포고동/서파탄적내약솔위20.0%、민감솔위73.3%,대기타항균약물적내약솔초과60.0%.범내약균점33.9%(21주),기중52.4%(11주)적범내약포만불동간균감염발생재ICU병방.결론 포만불동간균적내약솔교고,차정다중내약추세.가강균주적내약성감측,이약민결과지도림상용약유조우감소내약균주적출현.
Objective To investigate the prevalence and antimicrobial resistance of Acinetobacter baumannii in nosocomial infection.Methods Clinical features and the origin of A.baumannii samples were analyzed retrospectively.The minimal inhibitory concentration(MIC)and Kriby-Bauer diffusion test(K-B)were used to determine the Susceptibility to the antimicrobial agents.Results A total of 62 strains of A.baumannii were isolated from 2007 to 2010.Fifty-three strains(85.5%) of specimens were separated from respiratory tract.The isolation rate of A.baumannii was the highest in intensive care units(ICU)(21 strains,33.9%).54.8%(34/62)of patients suffered from severe lung infection.The resistance rate of cefoperazon/sulbactam was 20.0%.and the susceptible rate was 73.3%.The resistance rate to other antimicrobial agents is above 60.0%.The prevalence of multi-drug resistance of A.baumannii Was about 33.9%,and 52.4% of this kind of A.baumannii were occured in ICU.Condusion The infection of A.baumannii is more and more severe and tends to be resistant to multiple-drug and pan-drugs.The susceptible testing should be conducted to help the clinic to decrease the resistance rate.