CAJ | 학술논문

单克隆抗体(单抗)技术与分子生物学技术的结合使重组嵌合抗体、人源化抗体和全人抗体的技术得到迅速发展.由于这些单抗带有人抗体的Fc片段,因此,这些抗体不仅能中和抗原,更重要的是能介导细胞毒作用和激活补体系统.这些抗体已被用于治疗某些疾病,如癌症、免疫性疾病、感染性疾病和器官移植排斥.随着大规模CHO细胞生产工艺的发展,越来越多的单抗将应用于临床.
단극륭항체(단항)기술여분자생물학기술적결합사중조감합항체、인원화항체화전인항체적기술득도신속발전.유우저사단항대유인항체적Fc편단,인차,저사항체불부능중화항원,경중요적시능개도세포독작용화격활보체계통.저사항체이피용우치료모사질병,여암증、면역성질병、감염성질병화기관이식배척.수착대규모CHO세포생산공예적발전,월래월다적단항장응용우림상.
Combination of the technologies of the monoclonal antibody and molecular biology leads to rapid development of the techniques of chimeric antibody, humanized antibody and full human antibody. Because of having Fc region from human IgG, these antibodies can not only neutralize antigen, but also, most importantly, mediate ADCC and activate complement system. Monoclonal antibodies have been used in the treatment of some diseases, such as cancer, immune disease, infectious disease and organ transplant rejection. With the development of CHO cell culture process on a larger scale, more and more monoclonal antibodies will be in the clinical application.