CAJ | 학술논문

目的观察CTG方案[粒细胞集落刺激因子(G-CSF)、吡柔比星(THP)阿糖胞苷(Am-C)]治疗初治老年急性髓系白血病的临床疗效.方法对我院确诊的19例老年初治急性髓系白血病患者行CTG预激方案化疗,Ara-C 50 mg/d,第1～14天静脉滴注;THP 10mg/d,第1～6天静脉滴注,或隔日1次第1～10天静脉滴注;G-CSF每天200μg·m2,皮下注射,每日1次,在第1次注射Ara·C之前给予.如果白细胞>20 ×109/L暂停用G-CSF,而不停化疗,待白细胞回落后再用G-CSF.结果治疗2个疗程后,19例患者中完全缓解者7例(36.8%)、部分缓解者4例(21.0%)、无缓解者5例(26.3%)、中途放弃治疗3例.总有效率为57.9%(11/19).主要不良反应为消化道反应.结论 CTG预激方案治疗老年急性髓系白血病的疗效明显,耐受性好,不良反应小.
목적 관찰CTG방안[립세포집락자격인자(G-CSF)、필유비성(THP)아당포감(Am-C)]치료초치노년급성수계백혈병적림상료효.방법 대아원학진적19례노년초치급성수계백혈병환자행CTG예격방안화료,Ara-C 50 mg/d,제1～14천정맥적주;THP 10mg/d,제1～6천정맥적주,혹격일1차제1～10천정맥적주;G-CSF매천200μg·m2,피하주사,매일1차,재제1차주사Ara·C지전급여.여과백세포>20 ×109/L잠정용G-CSF,이불정화료,대백세포회락후재용G-CSF.결과 치료2개료정후,19례환자중완전완해자7례(36.8%)、부분완해자4례(21.0%)、무완해자5례(26.3%)、중도방기치료3례.총유효솔위57.9%(11/19).주요불량반응위소화도반응.결론 CTG예격방안치료노년급성수계백혈병적료효명현,내수성호,불량반응소.
Objective To evaluate the clinical efficacy and toxicity of Am- C and THP and G- CSF chemotherapy in elderly patients with acute myaloid leukemia. Methods 19 patients with newly diagnosed AML were administered with CTC chemotherapy schedule, which were intravenous injection Ara- C 50 mg/d from the 1st= day to 14th day and intravenous injection THP 10 mg/d from the 1st day to 6th day, or 10mg once a After 2 courses d induction therapy in patients with the priming induction regimen CAG and the total efficacy rate was 57.9% (11/19).36.8% (7/19) of the 19 patients were complete remission. 21.0% (4/19) of the 19 patients were partial remission. The main adverse effect was digestive response. Conclusions. It was a efficient and safe chemotherapy to elderly patients with acute myeloid leukemia of CIG. And it was well tolerance.