CAJ | 학술논문

脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是神经营养因子家族的重要成员之一,BDNF支持了发育期间一些神经系统神经元的生长与生存.BDNF是成年突触可塑性的一种重要调质.外周炎症、神经离断、神经损伤及神经病理性疼痛模型在内的多种疼痛均能改变神经系统内BDNF的表达.BDNF通过与其高亲和力受体酪氨酸激酶B(re-ceptior tyrosine kinase,TrkB)受体结合,从而激活下游信号通路发挥效应,在不同水平伤害性信息的调制中发挥了重要作用.
뇌원성신경영양인자(brain-derived neurotrophic factor,BDNF)시신경영양인자가족적중요성원지일,BDNF지지료발육기간일사신경계통신경원적생장여생존.BDNF시성년돌촉가소성적일충중요조질.외주염증、신경리단、신경손상급신경병이성동통모형재내적다충동통균능개변신경계통내BDNF적표체.BDNF통과여기고친화력수체락안산격매B(re-ceptior tyrosine kinase,TrkB)수체결합,종이격활하유신호통로발휘효응,재불동수평상해성신식적조제중발휘료중요작용.
Brain-derived neurotrophic factor (BDNF) is one of the important members of neurotrophin family. During brain development, BDNF supports the neuronal survival in central and peripheral nervous system, and acts as an important modulator of adult synaptic plasticity. BDNF expression occurs in nervous system in a number of pain models including pe.ripheral inflammation, axotomy, nerve injury and neuropathic pain paradigms. BDNF plays a critical role in modulation of nociceptive information at different levels via binding to tyrosine kinase receptor B (TrkB) and subsequently activating the downstream signaling pathways.