广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2012年
1期
45-46
,共2页
白杨素%白杨素衍生物%抗肿瘤活性%肿瘤细胞
白楊素%白楊素衍生物%抗腫瘤活性%腫瘤細胞
백양소%백양소연생물%항종류활성%종류세포
chrysin%chrysin derivates%anti-cancer activity%cancer cell
合成白杨素衍生物并对其进行活性评价。以5,7-二羟基黄酮为原料,通过取代、水解、酰胺缩合反应合成白杨素的衍生物,然后采用MTT比色法测定白杨素及白杨素衍生物对EC109（食管癌）、HepG2（肝癌）、SW480（结肠癌）、Hela（宫颈癌）细胞增殖抑制作用。合成的白杨素衍生物对HepG2、SW480肿瘤细胞的IC50值比白杨素的IC50值低。该衍生物对HepG2、SW480肿瘤细胞的抗癌活性较白杨素有一定程度的提高。
閤成白楊素衍生物併對其進行活性評價。以5,7-二羥基黃酮為原料,通過取代、水解、酰胺縮閤反應閤成白楊素的衍生物,然後採用MTT比色法測定白楊素及白楊素衍生物對EC109（食管癌）、HepG2（肝癌）、SW480（結腸癌）、Hela（宮頸癌）細胞增殖抑製作用。閤成的白楊素衍生物對HepG2、SW480腫瘤細胞的IC50值比白楊素的IC50值低。該衍生物對HepG2、SW480腫瘤細胞的抗癌活性較白楊素有一定程度的提高。
합성백양소연생물병대기진행활성평개。이5,7-이간기황동위원료,통과취대、수해、선알축합반응합성백양소적연생물,연후채용MTT비색법측정백양소급백양소연생물대EC109（식관암）、HepG2（간암）、SW480（결장암）、Hela（궁경암）세포증식억제작용。합성적백양소연생물대HepG2、SW480종류세포적IC50치비백양소적IC50치저。해연생물대HepG2、SW480종류세포적항암활성교백양소유일정정도적제고。
Chrysin derivate was synthesized to evaluate its biological activities.5,7-dihydroxyflavone as raw material and with the chemical methods of substitution reaction,hydrolysis and amide condensation reaction,the chrysin was synthesized,and then its antiproliferative activities against human cancer cell EC109,HepG2,SW480,and Hela were evaluated.The anti-caner activities against HepG2,SW480 of chrysin derivate manifestly increased,compared with chrysin.Compound 3 displayed better of anti-cancer activities than chrysin against HepG2,SW480.
