中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
4期
243-245
,共3页
林少达%段红艳%林楚佳%陈仲贤
林少達%段紅豔%林楚佳%陳仲賢
림소체%단홍염%림초가%진중현
糖尿病,2型%Ghielin%胰升血糖素%肥胖%胰岛素抵抗
糖尿病,2型%Ghielin%胰升血糖素%肥胖%胰島素牴抗
당뇨병,2형%Ghielin%이승혈당소%비반%이도소저항
Diabetes mellitus, type 2%Ghrelin% Glucagon% Obesity% Insulin resistance
目的 探讨肥胖及非肥胖2型糖尿病(T2DM)患者胰岛素抵抗(IR)与生长激素释放肽Gh-relin分泌的关系.方法 肥胖T2DM患者26例(Ob+T2DM组)及非4肥胖T2DM患者32例(Nob+T2DM组),正常对照30名(NC组)行胰升血糖素-GP释放试验,同步取血测定血浆Ghrelin和C-P.结果 (1)Ob+T2DM组空腹Gllrelin水平低于NC组和Nob+T2DM组(P＜0.05或P＜0.01);Ob+T2DM组FC-P及胰岛素抵抗指数(HOMA2-IR)高于NC组和Nob+T2DM组(P＜0.01或P＜0.05).静脉推注胰升血糖素后,NC组Ghrelin水平显著下降(P＜0.01),肥胖及非肥胖T2DM组Ghrelin水平无显著性改变.(2)Pearson相关分析显示空腹血浆Ghrelin水平分别与WC、BMI、体脂百分比、体脂重量呈负相关;多元回归分析显示腰围(WC)是Ghrelin水平的负性预测因子(回归方程Y＝4.814-0.0265X).(3)Ob+T2DM组中,空腹血浆Ghrelin水平分别与WC、BMI、体脂百分比、体脂重量、HOMA2-IR呈负相关.结论 外源性给予胰升血糖素对T2DM患者Ghrelin抑制效应减弱;肥胖T2DM患者血浆Ghre-lin水平较非肥胖患者明显降低,且与WC、BMI、体脂百分比、体脂重量、HOMA2-LR负相关;中心性肥胖T2DM患者血浆Ghrelin水平下降与LR有关.
目的 探討肥胖及非肥胖2型糖尿病(T2DM)患者胰島素牴抗(IR)與生長激素釋放肽Gh-relin分泌的關繫.方法 肥胖T2DM患者26例(Ob+T2DM組)及非4肥胖T2DM患者32例(Nob+T2DM組),正常對照30名(NC組)行胰升血糖素-GP釋放試驗,同步取血測定血漿Ghrelin和C-P.結果 (1)Ob+T2DM組空腹Gllrelin水平低于NC組和Nob+T2DM組(P＜0.05或P＜0.01);Ob+T2DM組FC-P及胰島素牴抗指數(HOMA2-IR)高于NC組和Nob+T2DM組(P＜0.01或P＜0.05).靜脈推註胰升血糖素後,NC組Ghrelin水平顯著下降(P＜0.01),肥胖及非肥胖T2DM組Ghrelin水平無顯著性改變.(2)Pearson相關分析顯示空腹血漿Ghrelin水平分彆與WC、BMI、體脂百分比、體脂重量呈負相關;多元迴歸分析顯示腰圍(WC)是Ghrelin水平的負性預測因子(迴歸方程Y＝4.814-0.0265X).(3)Ob+T2DM組中,空腹血漿Ghrelin水平分彆與WC、BMI、體脂百分比、體脂重量、HOMA2-IR呈負相關.結論 外源性給予胰升血糖素對T2DM患者Ghrelin抑製效應減弱;肥胖T2DM患者血漿Ghre-lin水平較非肥胖患者明顯降低,且與WC、BMI、體脂百分比、體脂重量、HOMA2-LR負相關;中心性肥胖T2DM患者血漿Ghrelin水平下降與LR有關.
목적 탐토비반급비비반2형당뇨병(T2DM)환자이도소저항(IR)여생장격소석방태Gh-relin분비적관계.방법 비반T2DM환자26례(Ob+T2DM조)급비4비반T2DM환자32례(Nob+T2DM조),정상대조30명(NC조)행이승혈당소-GP석방시험,동보취혈측정혈장Ghrelin화C-P.결과 (1)Ob+T2DM조공복Gllrelin수평저우NC조화Nob+T2DM조(P＜0.05혹P＜0.01);Ob+T2DM조FC-P급이도소저항지수(HOMA2-IR)고우NC조화Nob+T2DM조(P＜0.01혹P＜0.05).정맥추주이승혈당소후,NC조Ghrelin수평현저하강(P＜0.01),비반급비비반T2DM조Ghrelin수평무현저성개변.(2)Pearson상관분석현시공복혈장Ghrelin수평분별여WC、BMI、체지백분비、체지중량정부상관;다원회귀분석현시요위(WC)시Ghrelin수평적부성예측인자(회귀방정Y＝4.814-0.0265X).(3)Ob+T2DM조중,공복혈장Ghrelin수평분별여WC、BMI、체지백분비、체지중량、HOMA2-IR정부상관.결론 외원성급여이승혈당소대T2DM환자Ghrelin억제효응감약;비반T2DM환자혈장Ghre-lin수평교비비반환자명현강저,차여WC、BMI、체지백분비、체지중량、HOMA2-LR부상관;중심성비반T2DM환자혈장Ghrelin수평하강여LR유관.
Objective To study effects of exogenous glucagon on plasma ghrelin and obesity in type 2 diabetic patients. Methods The study subjects included the obese type 2 diabetics (Ob+T2DM, n=26), non-obese type 2 diabetics (NOb+T2DM, n=32) and normal control (NC, n=30). Plasma ghrelin and C-peptide were measured during glucagon stimulation test. Results The percent ghrelin inhibition induced by exogenous glucagon was lower in non-obese and obese T2DM (-0.1% and -4.1%, respectively with inter-subgroup difference at P＜0.05) than in normal control (-13.2%)(all P＜0.01). The plasma ghrelin was negatively correlated with waist circumference, BMI and body fat mass (γ value of -0.301 and P＜0.01; γ=-0.25 and P＜0.05; γ=-0.26 and P＜0.05, respectively) in normal control group, negatively correlated with WC, BMI, BFM and HOMA-IR in obese type 2 diabetes group (γ=-0.31 and P＜0.01; γ=-0.26 and P＜0.05; γ=-0.30 and P＜0.05; γ=0.30 and P＜0.05 respectively). Fasting ghrelin was independently correlated with waist circumference. Conclusions Fasting ghrelin level in obese T2DM group is lower than in non-obese T2DM group,and is correlated with waistline,body mass index,body fat percentage,body fat weight,HOMA2-IR.The decreasing of fasting ghrelin in central obese diabetic patients may be related with insulin resistance.
