CAJ | 학술논문

细胞内所有的蛋白质都在不断的被降解,并被新合成的蛋白质所取代.真核细胞内主要有两条蛋白降解途径,分别为泛素-蛋白酶体系统途径和自噬途径,两条途径都在维持细胞内稳态方面起着重要的作用.泛素-蛋白酶体系统是由泛素介导的一种高度复杂的蛋白降解机制,它通过一种特定的方式降解并再循环利用细胞内的蛋白,而自噬是一种自我降解过程,它通过溶酶体介导的方式降解蛋白.被降解的蛋白可以被提呈至MHCⅡ类分子或MHC Ⅰ类分子,从而激发有效的T细胞反应.此文就这两个途径参与蛋白降解及抗原提呈的相关研究进展进行综述.
세포내소유적단백질도재불단적피강해,병피신합성적단백질소취대.진핵세포내주요유량조단백강해도경,분별위범소-단백매체계통도경화자서도경,량조도경도재유지세포내은태방면기착중요적작용.범소-단백매체계통시유범소개도적일충고도복잡적단백강해궤제,타통과일충특정적방식강해병재순배이용세포내적단백,이자서시일충자아강해과정,타통과용매체개도적방식강해단백.피강해적단백가이피제정지MHCⅡ류분자혹MHC Ⅰ류분자,종이격발유효적T세포반응.차문취저량개도경삼여단백강해급항원제정적상관연구진전진행종술.
All proteins in cells are continually being degraded and replaced.Eukaryotes have two major intracellular protein degradation pathways,namely the ubiquitin-proteasome system and autophagy.Both of them are proteolytic pathways essential in the maintenance of cellular homeostasis.The ubiquitin-proteasom system is highly complex and mediated by ubiquitin,which participates in intracellular protein degradation in a specific manner.Autophagy is a self-degradation process that acts through a lysosome-mediated trafficking pathway to degrade and recycle intracellular components.Proteins degraded through the two pathways can be presented to MHC class Ⅱ molecules and MHC class Ⅰ molecules to stimulate efficient T-cell responses.This article reviews the advances on the two pathways involved in protein degradation and antigen presentation.