北京大学学报(医学版)
北京大學學報(醫學版)
북경대학학보(의학판)
JOURNAL OF PEAKING UNIVERSITY(HEALTH SCIENCES)
2001年
3期
228-232
,共5页
破伤风类毒素%微球%药物载体%体外研究
破傷風類毒素%微毬%藥物載體%體外研究
파상풍류독소%미구%약물재체%체외연구
目的：研究破伤风类毒素聚乳酸微球(TT-MS)的体外释放规律，考察附加剂对药物释放的影响。方法：破伤风类毒素聚乳酸微球体外释放试验进行了84 d，测定释放量，考察: （1）聚乳酸平均相对分子质量;（2）微球载药量;（3）微球粒径;（4）附加剂对药物释放的影响。结果：破伤风类毒素聚乳酸微球体外释放有显著的长效作用，释放模型为零级释放，释放速度与前面提到的4种影响因素直接相关。结论：所研究的聚乳酸微球可望发展成为疫苗控释系统。
目的：研究破傷風類毒素聚乳痠微毬(TT-MS)的體外釋放規律，攷察附加劑對藥物釋放的影響。方法：破傷風類毒素聚乳痠微毬體外釋放試驗進行瞭84 d，測定釋放量，攷察: （1）聚乳痠平均相對分子質量;（2）微毬載藥量;（3）微毬粒徑;（4）附加劑對藥物釋放的影響。結果：破傷風類毒素聚乳痠微毬體外釋放有顯著的長效作用，釋放模型為零級釋放，釋放速度與前麵提到的4種影響因素直接相關。結論：所研究的聚乳痠微毬可望髮展成為疫苗控釋繫統。
목적：연구파상풍류독소취유산미구(TT-MS)적체외석방규률，고찰부가제대약물석방적영향。방법：파상풍류독소취유산미구체외석방시험진행료84 d，측정석방량，고찰: （1）취유산평균상대분자질량;（2）미구재약량;（3）미구립경;（4）부가제대약물석방적영향。결과：파상풍류독소취유산미구체외석방유현저적장효작용，석방모형위령급석방，석방속도여전면제도적4충영향인소직접상관。결론：소연구적취유산미구가망발전성위역묘공석계통。
Objective: To study on in vitro release of tetanus toxoid contained in polylactide microsp heres and the influence of additives on the drug release. Methods: Some parameters affecting the rate of release were asse ssed during the in vitro experiments lasted 84 days: (1)the molecular mass of the poly mers , (2)the protein loading of the microspheres, (3)the particle sizes, (4)co-enca p sulation of additives. Results: The polylactide microspheres con taining tetanus toxoid presented considerable sustained release effect. Release kinetics of the microspheres fitted in with zero order equations. The rate of release was shown to dep end on the four parameters mentioned above. Conclusion: The poly lactide microsph eres investigated may be prospective for the development of controlled release v accines.
