CAJ | 학술논문

【目的】探索一种新的体外反搏实验装置和实验方法。【方法】自行设计制作一套适合比格犬清醒状态下长期接受反搏治疗的装置，该装置由反搏主机、反搏架、反搏内外囊套等组成。采用导管端式压力传感器检测主动脉根部压力，评价该系统的即时血流动力学效果。6条比格犬接受了即时血流动力学测定和长期体外反搏治疗，治疗总时间约28～30h不等（每日1次，每次1～2h），历时6～8周。【结果】反搏中实验犬的主动脉舒张期增压波可达(174.0±18.4)mmHg，显著高于反搏前的舒张压（P<0.01）。舒张压与收缩压比值（pD/pS）上升至1.24±0.05。此外，反搏过程中，主动脉收缩压平均下降达(19.22±8.70)mmHg。全部动物能顺利完成慢性体外反搏治疗观察，且动物的食欲、精神状态等无异常改变。【结论】该装置应用于体外反搏的慢性动物实验研究是可行的、有效的。
【목적】탐색일충신적체외반박실험장치화실험방법。【방법】자행설계제작일투괄합비격견청성상태하장기접수반박치료적장치，해장치유반박주궤、반박가、반박내외낭투등조성。채용도관단식압력전감기검측주동맥근부압력，평개해계통적즉시혈류동역학효과。6조비격견접수료즉시혈류동역학측정화장기체외반박치료，치료총시간약28～30h불등（매일1차，매차1～2h），력시6～8주。【결과】반박중실험견적주동맥서장기증압파가체(174.0±18.4)mmHg，현저고우반박전적서장압（P<0.01）。서장압여수축압비치（pD/pS）상승지1.24±0.05。차외，반박과정중，주동맥수축압평균하강체(19.22±8.70)mmHg。전부동물능순리완성만성체외반박치료관찰，차동물적식욕、정신상태등무이상개변。【결론】해장치응용우체외반박적만성동물실험연구시가행적、유효적。
【Objective】 To develop a new divice and approach for enhancedexternal counterpulsation (EECP) in awaking dogs. 【Methods】 The device was designed specially for dogs which consisted of main console, support frame, external and inner balloon cuffs. The hemodynamic effects of the new EECP device were examined in six beagle dogs by direct measurement of aortic pressure. The total EECP time was 28 to 30 hours (1～2 hours daily for each dog). 【Results】 The aortic diastolic pressure(pD) was highly enhanced when augmentation pressure increased to (174.0±18.4) mmHg (P<0.01) while aortic systolic pressure (pS) decreased by (19.22±8.70) mmHg with pD/pS ratio of 1.24±0.05 during EECP. These dogs didn′t develop any changes in appeptite and mental state during the long-term EECP experiment.【Conclusion】 The new device of EECP can achieve good hemodynamic effects and the EECP protocol conducted in this study is reliable and feasible for further study of EECP in awaking dogs.