CAJ | 학술논문

报道了18个(E)-4-酰氧基苯基丙烯酸类衍生物的设计与合成。其中17个化合物未见文献报道。所有目标物的化学结构经元素分析、红外光谱和核磁共振氢谱确证。初步体外抑癌试验结果表明，化合物3e、3f、3g、3h、3k、4h和4j在0.3 μmol·L-1浓度下对小鼠艾氏腹水癌(EAC)呈现显著抑制作用。
보도료18개(E)-4-선양기분기병희산류연생물적설계여합성。기중17개화합물미견문헌보도。소유목표물적화학결구경원소분석、홍외광보화핵자공진경보학증。초보체외억암시험결과표명，화합물3e、3f、3g、3h、3k、4h화4j재0.3 μmol·L-1농도하대소서애씨복수암(EAC)정현현저억제작용。
In the paper the design and synthesis of eighteen compounds of(E)-3-substituted- 4-aryloxyphenylpropenoic acid were reported.Among them seventeen final target compounds had never been reported.The chemical structures of all the target compounds were determined by elementary analysis and IR as well as 1H-NMR,etc.Preliminary results of anticancer tests in vitro showed that the test compounds 3e,3f,3g,3h,3k,4h and 4j had significantly anticancer activities on Ehrlich ascites carcinoma at 0.3 mmol·L-1 concentration.