CAJ | 학술논문

目的研究细菌性脑膜炎(BM)包括化脓性脑膜炎(PM)和结核性脑膜炎(TM)与病毒性脑膜炎(VME)患者急性期脑脊液中肿瘤坏死因子 ( TNFα)、粒细胞集落刺激因子(G-CSF)和可溶性白介素-2受体(SIL-2R)的变化，结合文献探讨它们的临床意义。方法 TNFα用放免法(RIA)，G-CSF和SIL-2R用ELISA法，检测25例PM、19例TM、22例VME脑脊液中 TNFα、G-CSF、IL-2R的含量，并与对照组对照。结果脑脊液中 TNFα和G-CSF含量在BM中较对照组显著增高(P<0.01)，同时BM较VME组亦明显升高(P<0.05)。 SIL-2R的含量在BM和VME组与对照组相比均增高(P<0.01)。结论说明BM和VME均引起免疫紊乱、免疫参与炎症反应中。 TNFα和G-CSF的改变可以作为BM和VEM早期鉴别诊断的指标之一。
목적연구세균성뇌막염(BM)포괄화농성뇌막염(PM)화결핵성뇌막염(TM)여병독성뇌막염(VME)환자급성기뇌척액중종류배사인자 ( TNFα)、립세포집락자격인자(G-CSF)화가용성백개소-2수체(SIL-2R)적변화，결합문헌탐토타문적림상의의。방법 TNFα용방면법(RIA)，G-CSF화SIL-2R용ELISA법，검측25례PM、19례TM、22례VME뇌척액중 TNFα、G-CSF、IL-2R적함량，병여대조조대조。결과뇌척액중 TNFα화G-CSF함량재BM중교대조조현저증고(P<0.01)，동시BM교VME조역명현승고(P<0.05)。 SIL-2R적함량재BM화VME조여대조조상비균증고(P<0.01)。결논설명BM화VME균인기면역문란、면역삼여염증반응중。 TNFα화G-CSF적개변가이작위BM화VEM조기감별진단적지표지일。
Objective　 To evaluated the levels of tumor necrosis factor-alpha(TNFa), granulocyte colony stimulating factor(G-CSF)and soluble interleukin-2 recepotor(SIL-2R)in cerebrospinal fluid, and analysized their value in differential diagnosis between bacterial meningitis and viral meningitis or encephlitis. Method　 The patients were classified into two groups:1. BM. bacterial meningitis (including: PM. pyogenous meningitis; TM. tuberculous meningitis) and 2.VME. Viral meningitis or encephlitis. The levels of TNFα were determined by RIA; The levels of G-CSF and SIL-2R were determined by ELISA. Results　 The levels of cerebrospinal fluid TNFα and G-CSF in BM were significantly higher than those in control group(P<0.01)and elevated level were not found in VEM(P<0.05). In addition, the TNFα and G-CSF in BM(PM,TM) were higher than in VME group(P<0.05). The levels of SIL-2R in BM and VME groups were significantly higher than that in control group(P<0.01). Conclusion　 All above shows: the disorder in immunity of the patients with BM and VME. We found concentration of cerebrospinal fluid TNFα and G-CSF can be a discriminating index between BM(PM,TM) and VME.