CAJ | 학술논문

目的　评估CA125监测进展期卵巢癌疗效及复发的应用价值。方法　采用ES300全自动酶免疫分析系统检测54例Ⅲ、Ⅳ期原发卵巢癌患者、42例综合治疗后随访卵巢癌患者、24例治疗后复发或远处转移患者、15例卵巢良性肿瘤和65例健康女性血清CA125水平。结果　(1）54例进展期原发卵巢癌患者血清CA125水平显著高于正常人和卵巢良性肿瘤患者。以35U/ml为限定值，卵巢上皮癌100%阳性，非上皮癌中2例内胚窦瘤为阴性，其余均阳性。良性肿瘤13.3%假阳性。Ⅲ、Ⅳ期间无显著差异。（2）原发卵巢癌患者经综合治疗后，CA125明显下降，病情转归与CA125下降的幅度相关，但与治疗前水平无关。（3）42例随访未出现复发者，102次检测CA125平均值为27.85±12.66U/ml，连续2次CA125升高者2例，治疗后复发或远处转移者24例，CA125平均值为339.55±246.6U/ml，其中95.8%（23/24）高于限定值。CA125判断复发的准确率为95.4%（63/66）。结论　CA125的连续监测可作为进展期卵巢癌疗效评价、复发转移及预后的一个有用指标。
목적　평고CA125감측진전기란소암료효급복발적응용개치。방법　채용ES300전자동매면역분석계통검측54례Ⅲ、Ⅳ기원발란소암환자、42례종합치료후수방란소암환자、24례치료후복발혹원처전이환자、15례란소량성종류화65례건강녀성혈청CA125수평。결과　(1）54례진전기원발란소암환자혈청CA125수평현저고우정상인화란소량성종류환자。이35U/ml위한정치，란소상피암100%양성，비상피암중2례내배두류위음성，기여균양성。량성종류13.3%가양성。Ⅲ、Ⅳ기간무현저차이。（2）원발란소암환자경종합치료후，CA125명현하강，병정전귀여CA125하강적폭도상관，단여치료전수평무관。（3）42례수방미출현복발자，102차검측CA125평균치위27.85±12.66U/ml，련속2차CA125승고자2례，치료후복발혹원처전이자24례，CA125평균치위339.55±246.6U/ml，기중95.8%（23/24）고우한정치。CA125판단복발적준학솔위95.4%（63/66）。결론　CA125적련속감측가작위진전기란소암료효평개、복발전이급예후적일개유용지표。
Objective　To evaluate the value of serum CA125 as a marker in monitoring efficiency and recurrence of advanced ovarian cancer.Method　ES300 automatic enzyme immune analysis system was used to detect the levels of serum CA125 in 54 stages Ⅲ and Ⅳ primary ovarian cancer patients,42 follow-up ovarian cancer patients,24 recurrent or metastatic patients,15 cases of benign ovarian tumors and 65 healthy control women.Results　(1)Pretreatment Serum CA125 levels in 54 advanced ovarian cancer patients were significantly higher than those in control group and ovarian benign tumors.Put 35 U/ml as critical value,CA125 levels were elevated in 100%(43/43) of epithelial ovarian cancer,and in 81.8%(9/11) of non epithelial ovarian cancer.There was no significant difference between stages Ⅲ and Ⅳ.(2)Serum CA125 levels decreased sharply after comprehensive therapy.The course of disease significantly correlated with the decrease range of serum CA125 after treatment,but did not correlate with the level before treatment.(3)In 42 follow-up patients without recurrence,102 times serum CA125 detection were carried out,there are only 2 patients whose serum CA125 increased in two series assays.Otherwise,serum CA125 increased over 35U/ml in 23/24(95.8%) of patients with recurrent or metastatic diseases.Diagnosis rate of CA125 for recurrent or metastatic diseases were up to 95.4(63/66).Conclusions　Series detection of serum CA125 is a useful index for evaluation of efficiency,recurrence，metastasis and prognosis.