CAJ | 학술논문

综述了内皮细胞生长抑制素的结构和功能；探讨了其与胶原蛋白Ⅹ　Ⅷ的关系以及抗血管生成、抗肿瘤生长和转移的可能机理；展望了其在肿瘤诊断、治疗等方面的应用前景.内皮细胞生长抑制素是胶原蛋白Ⅹ　ⅧC-末端的酶解产物，在血管生成过程中起负调控作用，通过阻断血管生成的信号并诱导内皮细胞的凋亡而特异性地抑制内皮细胞的迁移和新血管的生成，从而抑制肿瘤的生长和转移.其抗血管生成的机制目前尚未完全清楚，研究显示它是一个结合紧密的球状折叠分子，一面富含精氨酸残基，是肝素的结合位点，推测与抗血管生成的机制有关.内皮细胞生长抑制素作为抗肿瘤的内源性药物，具有高效性，低毒性，无耐药性等优点.
종술료내피세포생장억제소적결구화공능；탐토료기여효원단백Ⅹ　Ⅷ적관계이급항혈관생성、항종류생장화전이적가능궤리；전망료기재종류진단、치료등방면적응용전경.내피세포생장억제소시효원단백Ⅹ　ⅧC-말단적매해산물，재혈관생성과정중기부조공작용，통과조단혈관생성적신호병유도내피세포적조망이특이성지억제내피세포적천이화신혈관적생성，종이억제종류적생장화전이.기항혈관생성적궤제목전상미완전청초，연구현시타시일개결합긴밀적구상절첩분자，일면부함정안산잔기，시간소적결합위점，추측여항혈관생성적궤제유관.내피세포생장억제소작위항종류적내원성약물，구유고효성，저독성，무내약성등우점.
endostatin is a 20×103 C-terminal fragment of collagenⅩ　Ⅷ,which was found in vessel walls and basement membranes.The generation of endostatin from collagenⅩ　Ⅷ is catalyzed by proteolytic enzymes,including cathepsin L and matrix metalloproteases,that cleave peptide bonds within the protease-sensitive hinge region of the c-terminal domain.The processing of collagenⅩ　Ⅷ to endostatin may represent a local control mechanism for the regulation of angiogenesis.Endostatin specially inhibits endosthelial prolifeation and potently inhibits angiogenesis and tumor groth. Endostatin can induce endothelial cellapoptosis.The molecular mechanism behind the ihibition of angiogenesis have not yet been elucideted.Studies have shown that endostatin is a compact globular fold with one face particularly rich in argine residues acting as a haparin-binding epipote.It was initially suggested that zinc has a structural rather than a functional role in endostatin .As an endosgenous drugs of angiogenesis and tumor groth,endostatin has shown many advantages:highly effeciacy,lowest toxivity and no drug resistance.