CAJ | 학술논문

目的:研究CD15 mRNA表达与肝细胞癌(HCC)侵袭转移和预后的关系，以及与CD44v6 mRNA表达的相关性。方法:应用原位杂交和免疫组织化学方法，检测分析HCC组织中CD15 mRNA及其蛋白和CD44v6 mRNA的表达情况。结果:99例HCC中，CD15 mRNA及其蛋白和CD44v6阳性率表达分别为38.4%、36.4%和41.4%。CD15 mRNA表达与其蛋白表达一致，与CD44v6 mRNA表达关联性密切。CD15 mRNA及其蛋白和CD44v6 mRNA表达，均与HCC侵袭转移倾向和病人预后相关。结论:检测CD15表达有可能成为HCC侵袭转移和预后判断的一项新的病理生物学指标。
목적:연구CD15 mRNA표체여간세포암(HCC)침습전이화예후적관계，이급여CD44v6 mRNA표체적상관성。방법:응용원위잡교화면역조직화학방법，검측분석HCC조직중CD15 mRNA급기단백화CD44v6 mRNA적표체정황。결과:99례HCC중，CD15 mRNA급기단백화CD44v6양성솔표체분별위38.4%、36.4%화41.4%。CD15 mRNA표체여기단백표체일치，여CD44v6 mRNA표체관련성밀절。CD15 mRNA급기단백화CD44v6 mRNA표체，균여HCC침습전이경향화병인예후상관。결론:검측CD15표체유가능성위HCC침습전이화예후판단적일항신적병리생물학지표。
Objective：To investigate the association of the expression of CD15 mRNA with the invasion and prognosis of hepatocellular carcinoma(HCC) and the expression of CD44v6 mRNA.Methods：In situ hybridization and immunohistochemistry methods were used to detect the expression of CD15 mRNA and protein and CD44v6 mRNA in HCC.Results：In 99 cases of HCC, the positive rate of CD15 mRNA and protein and CD44v6 mRNA was 38.4%，36.4% and 41.4% respectively. The expression of CD15 mRNA was consistent with its protein, positively correlated with the expression of CD44v6 mRNA. The expression of CD15 mRNA and protein，CD44v6 mRNA were associated with the invasive and metastatic trend of HCC and the prognosis of HCC patients.Conclusion：The detection of CD15 expression could be a new pathological biology index to judge the metastasis and prognosis of HCC.