CAJ | 학술논문

目的：观察低分子肝素延长疗程治疗不稳定型心绞痛的疗效。方法：同期入院的不稳定型心绞痛患者168例，随机分为2组，均在常规治疗基础上应用低分子肝素(立迈青)皮下注射，每日2次。A组应用1周，B组应用3周，第1周用量2组均为每次120 IU/kg，第2～3周B组用量每次100 IU/kg。结果：早期(第7日)观察2组总有效率分别为75.9%、77.4%，疗效无显著差异(P>0.05)；心血管意外事件(急性心肌梗死、心脏性或非心脏性死亡、药物无法控制病情需行急性血运重建术)及出血，在2组的发生率无显著差异(P>0.05) 。晚期(第8～30日)观察2组总有效率分别为87.2%、97.5%，有显著性差异(P<0.05)；心血管意外事件发生率A组高于B组(P<0.05)；2组出血发生率无显著差异(P>0.05) 。结论：低分子肝素延长疗程治疗不稳定型心绞痛疗效较短程应用疗效为好，且不增加出血发生率。
목적：관찰저분자간소연장료정치료불은정형심교통적료효。방법：동기입원적불은정형심교통환자168례，수궤분위2조，균재상규치료기출상응용저분자간소(립매청)피하주사，매일2차。A조응용1주，B조응용3주，제1주용량2조균위매차120 IU/kg，제2～3주B조용량매차100 IU/kg。결과：조기(제7일)관찰2조총유효솔분별위75.9%、77.4%，료효무현저차이(P>0.05)；심혈관의외사건(급성심기경사、심장성혹비심장성사망、약물무법공제병정수행급성혈운중건술)급출혈，재2조적발생솔무현저차이(P>0.05) 。만기(제8～30일)관찰2조총유효솔분별위87.2%、97.5%，유현저성차이(P<0.05)；심혈관의외사건발생솔A조고우B조(P<0.05)；2조출혈발생솔무현저차이(P>0.05) 。결론：저분자간소연장료정치료불은정형심교통료효교단정응용료효위호，차불증가출혈발생솔。
Objective:To observe the curative effect of low molecular weight heparin of prolongable curative course on treating unstable angina pectoris.Methods:One hundred and sixtyeight cases with unstable angina pectoris who were admitted into hospital at the same period were randomly divided into two groups.Both groups were subcutaneously injected by low molecular weight heparin combined with conventional therapy,two times a day for one week in group A and three weeks in group B respectively.In the first week,the dosage of heparin in group A and B was 120 IU/kg every time,from second to third week,the dosage of heparin in group B was 100 IU/kg every time.Results:The total effective rates in group A and group B were 75.9% and 77.4% respectively in early stage (seventh day),and the difference was not significant (P>0.05).The incidences of cardiovascular accidental events (acute myocardial infarction,cardiac death,uncardiac death,the illness which could not be controlled by the medicine and should be treated with acute reconstruction of blood circulation) and haemorrhage in both groups had not significantly different (P>0.05).The total effective rates in group A and group B were 87.2% and 97.5% in advanced stage(eighth to 30th days) respectively,there was significantly difference (P<0.05).The incidence of cardiovascular accidental events in group A was higher than that in group B(P<0.05).The incidence of haemorrhage had not significantly different (P>0.05).Conclusions:The curative effect of low molecular weight heparin prolongable curative course is better than that with short curative course,and haemorrhagic incidence is not increased.