CAJ | 학술논문

目的：研究温补培元方治疗脾虚及脾肾阳虚证的作用机制。方法：采用利血平和大黄复制成的脾虚、脾肾阳虚动物模型，以温补培元方作为药物组，检测动物巨噬细胞功能、脾细胞自然杀伤(NK)细胞活性及刀豆素A(Con A)刺激的淋巴细胞掺入率(LIR)、红细胞免疫以及白细胞介素-2(IL-2)含量。结果：温补培元方组以上指标与病理模型组相比差异有显著性意义(P＜0.05，＜0.01)。结论：调节整个机体的细胞免疫，可能是温补培元方对脾虚、脾肾阳虚证作用的具体环节之一。
목적：연구온보배원방치료비허급비신양허증적작용궤제。방법：채용리혈평화대황복제성적비허、비신양허동물모형，이온보배원방작위약물조，검측동물거서세포공능、비세포자연살상(NK)세포활성급도두소A(Con A)자격적림파세포참입솔(LIR)、홍세포면역이급백세포개소-2(IL-2)함량。결과：온보배원방조이상지표여병리모형조상비차이유현저성의의(P＜0.05，＜0.01)。결론：조절정개궤체적세포면역，가능시온보배원방대비허、비신양허증작용적구체배절지일。
Objective：To research the mechanism of treatment of spleen deficiency and the deficiency of spleen yang and kidney yang by formula of warm tonification and reinforcing primary qi.Methods：The animal models of spleen deficiency and the deficiency of spleen yang and kidney yang were induced by Reserpine and Daihuang.The pharmacal group treated by the formula of warm tonification and reinforcing primary qi.The following indexes were observed:the function of macrophagocyte,the NK activity of splenocyte,lymphocyte incorporation rate stimulated by ConA,erythrocytic immune and the content of IL-2.Results：A significant differentiating was observed between pharmacal group and pathological model group(P＜0.01～0.05).Conclusion：Regulating the whole cellular immune function for insufficiency models may be the one of the effect mechanisms of formula of warm tonification and reinforcing primary qi.