中国现代应用药学
中國現代應用藥學
중국현대응용약학
CONTENTS IN BRIEF
2001年
1期
41-43
,共3页
漏德宝%薛艳%段更利%张彬%戴小平
漏德寶%薛豔%段更利%張彬%戴小平
루덕보%설염%단경리%장빈%대소평
双氯灭痛%软膏剂%透皮吸收%高效液相色谱法
雙氯滅痛%軟膏劑%透皮吸收%高效液相色譜法
쌍록멸통%연고제%투피흡수%고효액상색보법
目的:本实验采用高效液相色谱法,以离体小白鼠腹部皮肤为透皮屏障,比较了四种双氯灭痛软膏剂的透皮效果。方法:实验用法国Gilson公司的HPLC仪,以C18为固定相,甲醇-水(含HAc 0.36%)=80∶20为流动相,紫外检测波长280nm。平均回收率为99.59%,RSD<3.28%,检测限为1.0μg/ml。结果:1号样品透皮率最高,3号与1号相比较透皮吸收无显著性差异(P>0.05),2号或4号分别与1号相比,其透皮吸收均有显著性差异(P<0.05)。结论:1号样品值得进一步开发。
目的:本實驗採用高效液相色譜法,以離體小白鼠腹部皮膚為透皮屏障,比較瞭四種雙氯滅痛軟膏劑的透皮效果。方法:實驗用法國Gilson公司的HPLC儀,以C18為固定相,甲醇-水(含HAc 0.36%)=80∶20為流動相,紫外檢測波長280nm。平均迴收率為99.59%,RSD<3.28%,檢測限為1.0μg/ml。結果:1號樣品透皮率最高,3號與1號相比較透皮吸收無顯著性差異(P>0.05),2號或4號分彆與1號相比,其透皮吸收均有顯著性差異(P<0.05)。結論:1號樣品值得進一步開髮。
목적:본실험채용고효액상색보법,이리체소백서복부피부위투피병장,비교료사충쌍록멸통연고제적투피효과。방법:실험용법국Gilson공사적HPLC의,이C18위고정상,갑순-수(함HAc 0.36%)=80∶20위류동상,자외검측파장280nm。평균회수솔위99.59%,RSD<3.28%,검측한위1.0μg/ml。결과:1호양품투피솔최고,3호여1호상비교투피흡수무현저성차이(P>0.05),2호혹4호분별여1호상비,기투피흡수균유현저성차이(P<0.05)。결론:1호양품치득진일보개발。
OBJECTIVE:A HPLC method was established to determine the concentration of diclofenac sodium in transdermal absorption liquid.METHOD:A YWG-C18(10μm) colum was used with a mobile phase of CH3OH-H2O(including HAc 0.36%)(80∶20) at a flow rate of 1.0ml/min.UV detector was set at 280nm.The average recovery was 99.59% and the RSD were less than 3.28%.RESULTS:The No.1 and No.3 ointments had similar good effect on transdermal absorption(P>0.05) while the percutaneous release rate of No.1 was higher.The No.1 was absorbed more quickly than the No.2 and No.4(P<0.05).CONCLUSION:The No.1 ointment is valuable to be further developed.