CAJ | 학술논문

目的：研究应用以大剂量顺铂为主联合术前诱导化疗治疗口腔颌面部鳞癌和腺上皮癌的近期疗效和安全性。方法：对56例鳞癌，采用VCP联合化疗方案，对36例腺上皮癌采用VC5-Fu方案。化疗结束后，按照国际通用标准，对所治疗病例进行近期疗效分析，对药物的毒副反应进行观察。结果：VCP方案治疗56例鳞癌的近期有效率(缓解率)为83．9％，VC5-Fu方案治疗36例腺上皮癌的近期有效率为63．9％。两组的总有效率为73．9％。化疗的主要毒副反应为呕吐反应、骨髓抑制等。结论：以大剂量顺铂为主联合术前诱导化疗的近期疗效是肯定的，在口腔颌面部晚期恶性肿瘤的综合治疗中应该推广使用。加强对机体的保护性措施，可提高联合诱导化疗的安全性和疗效。
목적：연구응용이대제량순박위주연합술전유도화료치료구강합면부린암화선상피암적근기료효화안전성。방법：대56례린암，채용VCP연합화료방안，대36례선상피암채용VC5-Fu방안。화료결속후，안조국제통용표준，대소치료병례진행근기료효분석，대약물적독부반응진행관찰。결과：VCP방안치료56례린암적근기유효솔(완해솔)위83．9％，VC5-Fu방안치료36례선상피암적근기유효솔위63．9％。량조적총유효솔위73．9％。화료적주요독부반응위구토반응、골수억제등。결론：이대제량순박위주연합술전유도화료적근기료효시긍정적，재구강합면부만기악성종류적종합치료중응해추엄사용。가강대궤체적보호성조시，가제고연합유도화료적안전성화료효。
Objective:To observe the short term effect of preoperative inductive combined chemotherapy with high dose of cisplatin in the treatment of oral squamous carcinoma and acinic epithelioma. Methods :VCP combined chemotherapy was used in 56 cases with oral squamous carcinoma and VC5-Fu combimned chemotherapy in 36 with acinic epithelioma. When chemotherapy had finished, the short term curative effect was analyzed according to international standard and side effects of the drugs were observed. Results: The short term curative rate of VCP in the cases with oral squamous carcinomas was 83.9％ ,that of VC5-Fu in those with acinic epithelioma was 63.9％. The short term total curative rate in the 2 gronps was 73.9％. The main side effects of the chemotherapy were vomit and arrest of bone marrow etc. Conclusion :The preoperative inductive combined chemotherapy with high cisplatin is feasible for the treatment of oral squamous cell carcinoma and acinic epithelioma