CAJ | 학술논문

本文对5例已确诊为薄基底膜肾病的活检标本进行回顾性观察，首次采用选择性定位测量法，测量基底膜厚度，并与临床表现相联系，以提高对此病的认识与诊断。结果表明5例患者的肾小球基底膜厚度均<250mm，测量方法可靠。且基底膜厚度与血尿分级呈负相关(r=-0.39)，与病程呈正相关(r=0.65)。提示基底膜愈薄对红细胞的通透性愈大，而基底膜的广泛变薄可能是其发育不完善所致。
본문대5례이학진위박기저막신병적활검표본진행회고성관찰，수차채용선택성정위측량법，측량기저막후도，병여림상표현상련계，이제고대차병적인식여진단。결과표명5례환자적신소구기저막후도균<250mm，측량방법가고。차기저막후도여혈뇨분급정부상관(r=-0.39)，여병정정정상관(r=0.65)。제시기저막유박대홍세포적통투성유대，이기저막적엄범변박가능시기발육불완선소치。
In order to improve the diagnosis of thin basement membranenephropathy, we observed the ultrastructure of renal biopsy specimens from five cases with thin basement membrane nephropathy, and selectively measured the thickness of the basement membrane. The result showed: ① The thickness of the basement membrane of five patients was less than 250nm. ② The thickness of the basement membrane was positively related to the course of disease (r=0.65), While negatively related to the grade of haematuria (r=-0.39). The results suggest that hypoplasia may be the cause of extensively thinning of the basement membrane.